Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in embryos and larvae of the fathead minnow (Pimephales promelas)

被引：12

作者：

Olivieri, CE ^{[1
]}

Cooper, KR ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,COOK COLL,DEPT BIOCHEM MICROBIOL,NEW BRUNSWICK,NJ 08903

来源：

CHEMOSPHERE | 1997年 / 34卷 / 5-7期

关键词：

embryos; one-month-old larvae; fish; TCDD; toxicity;

D O I：

10.1016/S0045-6535(97)00414-1

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study evaluates the TCDD toxicity in embryos and larvae of the fathead minnow based on body burden. For the fish embryos, the LOAEL with mild lesions was at a tissue dose of 40 pg TCDD/g. The LD(50) was 25,710 pg TCDD/g. Embryos exhibited gross lesions such as multifocal hemorrhages, edema, and lower jaw malformation. For the one-month-old larvae, the NOAEL was at 3,590 pg TCDD/g. The LD(50) was 70,915 pg TCDD/g. Wasting-type syndrome was observed at a tissue dose of 20,000 pg TCDD/g, and 100% mortality at 163,000 pg TCDD/g. (C) 1997 Elsevier Science Ltd.

引用

页码：1139 / 1150

页数：12

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