The physical and chemical properties of eumelanin

被引:837
作者
Meredith, Paul
Sarna, Tadeusz [1 ]
机构
[1] Univ Queensland, Sch Phys Sci, Soft Condensed Matter Phys Grp, Brisbane, Qld, Australia
[2] Jagiellonian Univ, Dept Biophys, Fac Biochem Biophys & Biotechnol, Krakow, Poland
来源
PIGMENT CELL RESEARCH | 2006年 / 19卷 / 06期
关键词
eumelanin; physical and chemical properties; structure-property relationships; pheomelanin; metal ion binding; electron exchange; redox state; free radicals; photodynamics; photoreactivity; photoprotection; antioxidant action; quantum chemical calculations; energy gap; electrical conductivity;
D O I
10.1111/j.1600-0749.2006.00345.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In this article, we review the current state of knowledge concerning the physical and chemical properties of the eumelanin pigment. We examine properties related to its photoprotective functionality, and draw the crucial link between fundamental molecular structure and observable macroscopic behaviour. Where necessary, we also briefly review certain aspects of the pheomelanin literature to draw relevant comparison. A full understanding of melanin function, and indeed its role in retarding or promoting the disease state, can only be obtained through a full mapping of key structure-property relationships in the main pigment types. We are engaged in such an endeavor for the case of eumelanin.
引用
收藏
页码:572 / 594
页数:23
相关论文
共 165 条
[1]   STRUCTURAL DYNAMICS OF MELANIN INVESTIGATED BY RAYLEIGH-SCATTERING OF MOSSBAUER RADIATION [J].
ALBANESE, G ;
BRIDELLI, MG ;
DERIU, A .
BIOPOLYMERS, 1984, 23 (08) :1481-1498
[2]   ONE-ELECTRON OXIDATION OF METHOXYLATED AND HYDROXYLATED INDOLES BY N-3. .1. CHARACTERIZATION OF THE PRIMARY INDOLIC RADICALS [J].
ALKAZWINI, AT ;
ONEILL, P ;
ADAMS, GE ;
CUNDALL, RB ;
JACQUET, B ;
LANG, G ;
JUNINO, A .
JOURNAL OF PHYSICAL CHEMISTRY, 1990, 94 (17) :6666-6670
[3]   The epidemiology of UV induced skin cancer [J].
Armstrong, BK ;
Kricker, A .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2001, 63 (1-3) :8-18
[4]  
BARKER D, 1995, CANCER RES, V55, P4041
[5]   Multiphoton excited fluorescence spectroscopy of biomolecular systems [J].
Birch, DJS .
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2001, 57 (11) :2313-2336
[6]   Fundamental building blocks of eumelanins: electronic properties of indolequinone-dimers [J].
Bochenek, K ;
Gudowska-Nowak, E .
CHEMICAL PHYSICS LETTERS, 2003, 373 (5-6) :532-538
[7]   Geometric and spectroscopic study of some molecules related to eumelanins.: 1.: Monomers [J].
Bolívar-Marinez, LE ;
Galvao, DS ;
Caldas, MJ .
JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (15) :2993-3000
[8]  
BORAVANSKY J, 2002, PIGMENT CELL RES, V16, P280
[9]   Retinal photodamage [J].
Boulton, M ;
Rózanowska, M ;
Rózanowski, B .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2001, 64 (2-3) :144-161
[10]   INCORPORATION OF VARIOUS METAL IONS INTO IN VIVO- AND IN VITRO-PRODUCED MELANIN [J].
BRUENGER, FW ;
STOVER, BJ ;
ATHERTON, DR .
RADIATION RESEARCH, 1967, 32 (01) :1-&