Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

被引：18

作者：

Dong, Zuoqing ^{[1
]}

Liu, Shaohua ^{[1
]}

Zhou, Chengjun ^{[2
]}

Sumida, Tomoki ^{[3
]}

Hamakawa, Hiroyuki ^{[3
]}

Chen, Zhenggang ^{[1
]}

Liu, Pei ^{[1
]}

Wei, Fengcai ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Oral & Maxillofacial Surg, Jinan 250012, Peoples R China

[2] Shandong Univ, Dept Pathol, Hosp 2, Jinan 250033, Peoples R China

[3] Ehime Univ, Grad Sch Med, Dept Oral & Maxillofacial Surg, Matsuyama, Ehime 7910295, Japan

来源：

ORAL ONCOLOGY | 2010年 / 46卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Id-1; Oral squamous cell carcinoma; Angiogenesis; Prognosis; LOOP-HELIX PROTEINS; PROSTATE-CANCER; BREAST-CANCER; GROWTH; DIFFERENTIATION; EXPRESSION; REGULATOR; VEGF;

D O I：

10.1016/j.oraloncology.2009.11.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p = 0.013), lymph node metastasis (p = 0.001), tumor stage (p = 0.031) and tumor recurrence (p = 0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r = 0.223, p = 0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：154 / 157

页数：4

共 17 条

[1] The Id proteins and angiogenesis [J].

Benezra, R ;

Rafii, S ;

Lyden, D .

ONCOGENE, 2001, 20 (58) :8334-8341

[2] THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS [J].

BENEZRA, R ;

DAVIS, RL ;

LOCKSHON, D ;

TURNER, DL ;

WEINTRAUB, H .

CELL, 1990, 61 (01) :49-59

[3] Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism [J].

Deed, RW ;

Armitage, S ;

Norton, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (39) :23603-23606

[4]

Hansen S, 1998, LAB INVEST, V78, P1563

[5]

KADESCH T, 1993, CELL GROWTH DIFFER, V4, P49

[6]

Langlands K, 2000, CANCER RES, V60, P5929

[7] Id proteins at the cross-road of development and cancer [J].

Lasorella, A ;

Uo, T ;

Iavarone, A .

ONCOGENE, 2001, 20 (58) :8326-8333

[8] Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF) [J].

Ling, MT ;

Lau, TCM ;

Zhou, C ;

Chua, CW ;

Kwok, WK ;

Wang, Q ;

Wang, XH ;

Wong, YC .

CARCINOGENESIS, 2005, 26 (10) :1668-1676

[9] Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts [J].

Lyden, D ;

Young, AZ ;

Zagzag, D ;

Yan, W ;

Gerald, W ;

O'Reilly, R ;

Bader, BL ;

Hynes, RO ;

Zhuang, Y ;

Manova, K ;

Benezra, R .

NATURE, 1999, 401 (6754) :670-677

[10] Id-1: Regulator of EGFR and VEGF and potential target for colorectal cancer therapy [J].

Meteoglu, Ibrahim ;

Meydan, Nezih ;

Erkus, Muhan .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2009, 27

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