A novel duplication type of CYP2A6 gene in African-American population

被引:39
作者
Fukami, Tatsuki
Nakajima, Miki [1 ]
Yamanaka, Hiroyuki
Fukushima, Yasunari
McLeod, Howard L.
Yokoi, Tsuyoshi
机构
[1] Kanazawa Univ, Div Pharmaceut Sci, Grad Sch Med Sci, Kanazawa, Ishikawa 9201192, Japan
[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
关键词
D O I
10.1124/dmd.106.013557
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Human CYP2A6 is responsible for the metabolism of nicotine and its genetic polymorphisms affect smoking behavior and risk of lung cancer. In the present study, we identified a novel type of CYP2A6 gene duplication that is created through an unequal crossover event with the CYP2A7 gene at 5.2 to 5.6 kilobases downstream from the stop codon. The novel duplication type of CYP2A6 was found in African Americans ( n = 176) at an allele frequency of 1.7%, but was not found in European-American ( n = 187), Korean ( n = 209), or Japanese ( n = 184) populations. The plasma cotinine/ nicotine ratio in subjects possessing the novel CYP2A6 gene duplication with the CYP2A6*1 allele ( 10.8 +/- 7.0, n = 4) was 1.4-fold higher than that in homozygotes of the wild type (8.0 +/- 5.0, n = 87), although the difference was not statistically significant. The findings in the present study suggested that the novel duplicated CYP2A6 allele, which is specific for African Americans, would increase nicotine metabolism and may affect smoking behavior.
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收藏
页码:515 / 520
页数:6
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