Antimicrobial Resistance in Hospitalized Patients with Community Acquired Urinary Tract Infection in Isfahan, Iran

被引：6

作者：

Mostafavi, Sayed Nassereddin ^{[1
,2
]}

Rostami, Soodabeh ^{[3
]}

Nejad, Yasamin Rezaee ^{[1
]}

Ataei, Behrooz ^{[1
]}

Mobasherizadeh, Sina ^{[3
]}

Cheraghi, Aazam ^{[4
]}

Haghighipour, Somayeh ^{[1
]}

Nouri, Samereh ^{[5
]}

Pourdad, Arezoo ^{[6
]}

Ataabadi, Parisa ^{[6
]}

Almasi, Nasser ^{[7
]}

Heidary, Leila ^{[7
]}

Naderi, Kourosh ^{[7
]}

Korangbeheshti, Setareh ^{[7
]}

Navabi, Shiva ^{[8
]}

Masssah, Laleh ^{[8
]}

Norouzi, Zohreh ^{[8
]}

Bakhtiyaritabar, Mehrnoush ^{[8
]}

Moayednia, Saeed ^{[5
]}

Shokri, Dariush ^{[3
]}

Mikhak, Mahin ^{[7
]}

Rahmani, Majid ^{[8
]}

Hashemi, Mohammad ^{[9
]}

Etminani, Reza ^{[4
]}

Ahmadi, Nasrin ^{[4
]}

Kelishadi, Roya ^{[2
]}

机构：

[1] Isfahan Univ Med Sci, Infect Dis & Trop Med Res Ctr, Esfahan, Iran

[2] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Esfahan, Iran

[3] Isfahan Univ Med Sci, Nosocomial Infect Res Ctr, Esfahan, Iran

[4] Isfahan Univ Med Sci, Vice Chancelleries Clin Affairs, Esfahan, Iran

[5] Alzahra Med Ctr, Dept Microbiol, Clin Lab, Esfahan, Iran

[6] Isfahan Univ Med Sci, Alzahra Med Ctr, Esfahan, Iran

[7] Dr Shariati Hosp, Isfahan Social Secur Org, Esfahan, Iran

[8] Dr Gharazi Hosp, Isfahan Social Secur Org, Esfahan, Iran

[9] Isfahan Univ Med Sci, Intervent Res Ctr, Cardiovasc Dept, Esfahan, Iran

来源：

ARCHIVES OF IRANIAN MEDICINE | 2021年 / 24卷 / 03期

关键词：

Antimicrobial susceptibility; Community acquired; Hospitalized; Infection; Iran; Urinary tract; UROPATHOGENS; PATHOGENS; PATTERNS; CHILDREN;

D O I：

10.34172/aim.2021.29

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Antibiotic resistance against uro-pathogens is a worldwide health concern. The aim of this study was to determine the causative bacteria and antibiotic susceptibility patterns among hospitalized patients with community acquired urinary tract infection (UTI). Methods: This cross-sectional study was performed in 2016-2018 in Isfahan, Iran. Urine samples were examined for strain identification and antimicrobial resistance pattern using standard tests. Stratification was done based on gender and age (<20 and >20 years) groups. Chi-square and Fisher exact tests were applied to assess differences in etiology and susceptibility rates between groups. Results: Among 1180 patients, Escherichia coli was the commonest pathogen (68.1%) followed by Enterococcus spp. (8.8%) and Klebsiella pneumonia (8.0 %). Non -E. coli pathogens were more frequent among males (41.8% versus 24.8% in females, P < 0.01) and in those aged under 20 years (61.0% versus 22.2% in older than 20 years, P < 0.01). Isolated bacteria revealed high susceptibility to imipenem (94.9%), meropenem (92.2%), and amikacin (91.9%); moderate sensitivity to gentamicin (64.4%), cefepime (52.6%) and ceftazidime (47.2%); and low susceptibility to ceftriaxone (41.8%), cefotaxime (40.0%), ciprofloxacin (38.6%) and trimethoprim-sulfamethoxazol (31.3%). The sensitivity of isolates to ceftriaxone, ceftazidime, cefepime, imipenem, meropenem, amikacin and ciprofloxacin was significantly higher in females. Compared to the older age group, uro-pathogens were more susceptible to ciprofloxacin, ceftazidime and gentamicin in patients aged under 20 years. Conclusion: We found that imipenem, meropenem and amikacin were good choices for empiric therapy of complicated or severe hospitalized patients with community acquired UTI; and gentamicin, cefepime and ceftazidime were acceptable as initial choices in non-severe infections in the area.

引用

页码：187 / 192

页数：6

共 21 条

[11] Pattern of Antibacterial Resistance in Urinary Tract Infections: A Systematic Review and Meta-analysis [J].