Design, synthesis, and anticancer activity of novel aryl/heteroaryl chalcone derivatives

被引：9

作者：

Arasavelli, Ananda Mohan ^{[4
,5
]}

Sharma, Ganapavarapu Veera Raghava ^{[1
]}

Vidavalur, Siddaiah ^{[2
,3
]}

机构：

[1] GITAM Univ, GIT, Dept Chem, Visakhapatnam 530045, Andhra Pradesh, India

[2] Andhra Univ, Dept Organ Chem, Visakhapatnam 530003, Andhra Pradesh, India

[3] Andhra Univ, FDW, Visakhapatnam 530003, Andhra Pradesh, India

[4] Dr BR Ambedkar Univ, Dept Organ Chem, Etcherla 532410, Andhra Pradesh, India

[5] Jawaharlal Nehru Technol Univ Kakinada, Dept Chem, Kakinada 533003, Andhra Pradesh, India

来源：

HETEROCYCLIC COMMUNICATIONS | 2016年 / 22卷 / 01期

关键词：

anti-cancer; arylboronic acids; 3-arylthiophene; 3-bromothiophen-2-carbaldehyde; chalcones; LDA; ARYLATION; GROWTH;

D O I：

10.1515/hc-2015-0271

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of chalcones 5a-l were synthesized and evaluated for in vitro antiproliferative activity against human colon cancer cell lines. The synthesis of the key intermediate compounds 3a-d was achieved by tetrakis(triphenylphosphine) palladium(II) mediated Suzuki cross coupling reaction. Chalcone 5a shows superior anticancer activity with IC50 value of 21.0 mu g/mL compared to the IC50 value of the reference drug doxorubicin at 21.65 mu g/mL.

引用

页码：1 / 5

页数：5

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