Characterizing memory loss in patients with autoimmune limbic encephalitis hippocampal lesions

被引:10
作者
Lad, Meher [1 ]
Mullally, Sinead L. [1 ]
Houston, Alexandra L. [1 ]
Kelly, Tom [2 ]
Griffiths, Timothy D. [1 ,3 ]
机构
[1] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England
[2] Royal Victoria Infirm, Neuropsychol Dept, Newcastle Upon Tyne, Tyne & Wear, England
[3] UCL, Wellcome Trust Ctr Neuroimaging, London, England
基金
英国惠康基金;
关键词
episodic memory; hippocampus; recall memory; recognition memory; retrograde-amnesia; semantic memory; voltage-gated potassium channel complex antibody associated limbic encephalitis (VGKCC-Ab LE); MEDIAL-TEMPORAL-LOBE; POTASSIUM CHANNEL ANTIBODIES; GLIOMA-INACTIVATED; RETROGRADE-AMNESIA; AUTOBIOGRAPHICAL MEMORY; RECOGNITION MEMORY; SEMANTIC MEMORY; LEUCINE-RICH; FAMILIARITY; RECOLLECTION;
D O I
10.1002/hipo.23150
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Since the publication of Scoville and Milner's (1957) seminal paper, the precise functional role played by the hippocampus in support of human memory has been fiercely debated. For instance, the single question of whether the hippocampus plays a time-limited or an indelible role in the recollection of personal memories led to a deep and tenacious schism within the field. Similar polarizations arose between those who debated the precise nature of the role played by the hippocampus in support of semantic relative to episodic memories and in recall/recollection relative to familiarity-based recognition. At the epicenter of these divisions lies conflicting neuropsychological findings. These differences likely arise due to the consistent use of heterogeneous patient populations to adjudicate between these positions. Here we utilized traditional neuropsychological measures in a homogenous patient population with a highly discrete hippocampal lesion (i.e., VGKCC-Ab related autoimmune limbic encephalitis patients). We observed consistent impairment of recent episodic memories, a present but less striking impairment of remote episodic memories, preservation of personal semantic memory, and recall but not recognition memory deficits. We conclude that this increasingly well-characterized patient group may represent an important homogeneous population in which the functional role played by the hippocampus may be more precisely delineated.
引用
收藏
页码:1114 / 1120
页数:7
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