A new asymmetric 1,4-addition method: application to the synthesis of the HIV non-nucleoside reverse transcriptase inhibitor DPC 961

被引：47

作者：

Magnus, NA ^{[1
]}

Confalone, PN ^{[1
]}

Storace, L ^{[1
]}

机构：

[1] DuPont Pharmaceut Co, Chem Proc R&D, Chambers Works, Deepwater, NJ 08023 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)00331-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric synthesis of the HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) DPC 961 is achieved in three steps with an overall yield of >55%. The asymmetry is induced by the chiral auxiliary (R)-(+)-alpha-methylbenzylamine, utilizing a new asymmetric 1,4-addition protocol. (C) 2000 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3015 / 3019

页数：5

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