Cortical Thickness Analysis to Detect Progressive Mild Cognitive Impairment: A Reference to Alzheimer's Disease

被引:44
作者
Julkunen, Valtteri [1 ]
Niskanen, Eini [2 ,3 ]
Muehlboeck, Sebastian [6 ]
Pihlajamaki, Maija [1 ,3 ]
Kononen, Mervi [4 ,5 ]
Hallikainen, Merja [3 ]
Kivipelto, Miia [1 ,7 ]
Tervo, Susanna [3 ]
Vanninen, Ritva [4 ]
Evans, Alan [6 ]
Soininen, Hilkka [1 ,3 ]
机构
[1] Kuopio Univ Hosp, Dept Neurol, FI-70211 Kuopio, Finland
[2] Univ Kuopio, Dept Phys, FIN-70211 Kuopio, Finland
[3] Univ Kuopio, Inst Clin Med, Neurol Unit, FIN-70211 Kuopio, Finland
[4] Kuopio Univ Hosp, Dept Clin Radiol, FI-70211 Kuopio, Finland
[5] Kuopio Univ Hosp, Dept Clin Neurophysiol, FI-70211 Kuopio, Finland
[6] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada
[7] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden
基金
芬兰科学院;
关键词
Alzheimer's disease; Mild cognitive impairment; Cortical thickness; Magnetic resonance imaging; VOXEL-BASED MORPHOMETRY; AUTOMATED 3-D EXTRACTION; BRAIN ATROPHY; ENTORHINAL CORTEX; PATTERN-CLASSIFICATION; HIPPOCAMPAL VOLUME; STRUCTURAL-CHANGES; SPATIAL-PATTERNS; MCI PATIENTS; MRI;
D O I
10.1159/000256274
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background/Aims: Mild cognitive impairment (MCI) is associated with an increased risk of Alzheimer's disease (AD). It would be advantageous to be able to distinguish the characteristics of those MCI patients with a high probability to progress to AD if one wishes to monitor the disease development and treatment. Methods: We assessed the baseline MRI and maximum of 7 years clinical follow-up data of 60 MCI subjects in order to examine differences in cortical thickness (CTH) between the progressive MCI (P-MCI) and stable MCI (S-MCI) subjects. CTH was measured using an automatic computational surface-based method. During the follow-up, 15 MCI subjects converted to AD on average 1.9 8 +/- 1.3 years after the baseline examination, while 45 MCI subjects remained stable. Results: The P-MCI group displayed significantly reduced CTH bilaterally in the superior and middle frontal, superior, middle and inferior temporal, fusiform and parahippocampal regions as well as the cingulate and retrosplenial cortices and also in the right precuneal and paracentral regions compared to S-MCI subjects. Conclusions: Analysis of CTH could be used in conjunction with neuropsychological testing to identify those subjects with imminent conversion from MCI to AD several years before dementia diagnosis. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码:404 / 412
页数:9
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