Base Editing Landscape Extends to Perform Transversion Mutation

被引：30

作者：

Molla, Kutubuddin A. ^{[1
]}

Qi, Yiping ^{[2
,3
]}

Karmakr, Subhasis ^{[1
]}

Baig, Mirza J. ^{[1
]}

机构：

[1] Indian Council Agr Res ICAR, Natl Rice Res Inst NRRI, Cuttack 753006, Orissa, India

[2] Univ Maryland, Dept Plant Sci & Landscape Architecture, College Pk, MD 20742 USA

[3] Univ Maryland, Inst Biosci & Biotechnol Res, Rockville, MD 20850 USA

来源：

TRENDS IN GENETICS | 2020年 / 36卷 / 12期

基金：

美国国家科学基金会;

关键词：

GENOMIC DNA;

D O I：

10.1016/j.tig.2020.09.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Base editors have drawn considerable academic and industrial attention in recent years because of their ability to alter single DNA bases with precision. However, the existing cytosine and adenine base editors can only install transition mutations. Three recent studies (Kurt et al., Zhao et al., and Chen et al.) expand the base editing toolbox by developing cytosine transversion base editors.

引用

页码：899 / 901

页数：3

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