共 48 条
Ambient air pollution: a cause of COPD?
被引:130
作者:
Schikowski, Tamara
[1
,2
]
Mills, Inge C.
[3
]
Anderson, H. Ross
[4
,5
]
Cohen, Aaron
[7
]
Hansell, Anna
[6
]
Kauffmann, Francine
[8
,9
]
Kraemer, Ursula
[10
]
Marcon, Alessandro
[11
]
Perez, Laura
[1
,2
]
Sunyer, Jordi
[12
,13
]
Probst-Hensch, Nicole
[1
,2
]
Kuenzli, Nino
[1
,2
]
机构:
[1] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland
[2] Univ Basel, Basel, Switzerland
[3] Hlth Protect Agcy HPA Ctr Radiat Chem & Environm, Chilton, England
[4] Univ London, Med Res Council MRC HPA Ctr Environm & Hlth, London, England
[5] Kings Coll London, MRC HPA Ctr Environm & Hlth, London WC2R 2LS, England
[6] Univ London Imperial Coll Sci Technol & Med, MRC HPA Ctr Environm & Hlth, London, England
[7] Hlth Effects Inst, Boston, MA USA
[8] CESP Ctr Res Epidemiol & Populat Hlth, INSERM, U1018, Resp & Environm Epidemiol Team, Villejuif, France
[9] Univ Paris 11, UMRS 1018, Villejuif, France
[10] IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany
[11] Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37100 Verona, Italy
[12] Ctr Res Environm Epidemiol, Barcelona, Spain
[13] Univ Pompeu Fabra, Barcelona, Spain
基金:
瑞士国家科学基金会;
关键词:
OBSTRUCTIVE PULMONARY-DISEASE;
LONG-TERM EXPOSURE;
LUNG-FUNCTION;
GLOBAL BURDEN;
RISK-FACTORS;
MORTALITY;
ASTHMA;
EXACERBATIONS;
SYMPTOMS;
DECLINE;
D O I:
10.1183/09031936.00100112
中图分类号:
R56 [呼吸系及胸部疾病];
学科分类号:
摘要:
The role of ambient air pollution in the development of chronic obstructive pulmonary disease (COPD) is considered to be uncertain. We review the evidence in the light of recent studies. Eight morbidity and six mortality studies were identified. These were heterogeneous in design, characterisation of exposure to air pollution and methods of outcome definition. Six morbidity studies with objectively defined COPD (forced expiratory volume in 1 s/forced vital capacity ratio) were cross-sectional analyses. One longitudinal study defined incidence of COPD as the first hospitalisation due to COPD. However, neither mortality nor hospitalisation studies can unambiguously distinguish acute from long-term effects on the development of the underlying pathophysiological changes. Most studies were based on within-community exposure contrasts, which mainly assess traffic-related air pollution. Overall, evidence of chronic effects of air pollution on the prevalence and incidence of COPD among adults was suggestive but not conclusive, despite plausible biological mechanisms and good evidence that air pollution affects lung development in childhood and triggers exacerbations in COPD patients. To fully integrate this evidence in the assessment, the life-time course of COPD should be better defined. Larger studies with longer follow-up periods, specific definitions of COPD phenotypes, and more refined and source-specific exposure assessments are needed.
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页码:250 / 263
页数:14
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