Azoospermia due to Spermatogenic Failure

被引：54
作者：
Berookhim, Boback M.
Schlegel, Peter N.
机构：
[1] Department of Urology, Weill Cornell Medical College, New York, NY 10065
[2] Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021
[3] Center for Biomedical Research, The Population Council, New York, NY 10021
来源：
UROLOGIC CLINICS OF NORTH AMERICA | 2014年 / 41卷 / 01期
关键词：
TESTICULAR SPERM EXTRACTION; FINE-NEEDLE-ASPIRATION; HUMAN CHORIONIC-GONADOTROPIN; GERM-CELL TRANSPLANTATION; Y-CHROMOSOME MICRODELETION; LATE MATURATION ARREST; NONOBSTRUCTIVE AZOOSPERMIA; INFERTILE MEN; INTRACYTOPLASMIC SPERM; KLINEFELTER-SYNDROME;
D O I：
10.1016/j.ucl.2013.08.004
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
This article summarizes the current literature regarding azoospermia caused by spermatogenic failure. The causes and genetic contributions to spermatogenic failure are reviewed. Medical therapies including use of hormonal manipulation, whether guided by a specific abnormality or empiric, to induce spermatogenesis are discussed. The role of surgical therapy, including a discussion of varicocelectomy in men with spermatogenic failure, as well as an in-depth review of surgical sperm retrieval with testicular sperm extraction and microdissection testicular sperm extraction, is provided. Finally, future directions of treatment for men with spermatogenic failure are discussed, namely, stem cell and gene therapy.
引用
收藏
页码：97 / +
页数：18
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