Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

被引：1455

作者：

Tanaka, K

Watase, K

Manabe, T

Yamada, K

Watanabe, M

Takahashi, K

Iwama, H

Nishikawa, T

Ichihara, N

Hori, S

Takimoto, M

Wada, K

机构：

[1] UNIV TOKYO,FAC MED,DEPT NEUROPHYSIOL,TOKYO 113,JAPAN

[2] HOKKAIDO UNIV,SCH MED,DEPT ANAT,SAPPORO,HOKKAIDO 060,JAPAN

[3] NATL INST NEUROSCI,DEPT ANIM MODELS HUMAN DIS,KODAIRA,TOKYO 187,JAPAN

[4] TAISHO PHARMACEUT CO LTD,MED RES LABS,LAB 1,OMIYA,SAITAMA 330,JAPAN

[5] CIBA GEIGY JAPAN,INT RES LABS,TAKARAZUKA,HYOGO 665,JAPAN

来源：

SCIENCE | 1997年 / 276卷 / 5319期

关键词：

D O I：

10.1126/science.276.5319.1699

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.

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收藏

页码：1699 / 1702

页数：4

相关论文

共 27 条

[1] GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].

CHOI, DW .

NEURON, 1988, 1 (08) :623-634

[2] THE TIME COURSE OF GLUTAMATE IN THE SYNAPTIC CLEFT [J].

CLEMENTS, JD ;

LESTER, RAJ ;

TONG, G ;

JAHR, CE ;

WESTBROOK, GL .

SCIENCE, 1992, 258 (5087) :1498-1501

[3] THE ROLE OF EXCITATORY AMINO-ACIDS AND NMDA RECEPTORS IN TRAUMATIC BRAIN INJURY [J].

FADEN, AI ;

DEMEDIUK, P ;

PANTER, SS ;

VINK, R .

SCIENCE, 1989, 244 (4906) :798-800

[4] AN EXCITATORY AMINO-ACID TRANSPORTER WITH PROPERTIES OF A LIGAND-GATED CHLORIDE CHANNEL [J].

FAIRMAN, WA ;

VANDENBERG, RJ ;

ARRIZA, JL ;

KAVANAUGH, MP ;

AMARA, SG .

NATURE, 1995, 375 (6532) :599-603

[5] THE UPTAKE INHIBITOR L-TRANS-PDC ENHANCES RESPONSES TO GLUTAMATE BUT FAILS TO ALTER THE KINETICS OF EXCITATORY SYNAPTIC CURRENTS IN THE HIPPOCAMPUS [J].

ISAACSON, JS ;

NICOLL, RA .

JOURNAL OF NEUROPHYSIOLOGY, 1993, 70 (05) :2187-2191

[6] PRIMARY STRUCTURE AND FUNCTIONAL-CHARACTERIZATION OF A HIGH-AFFINITY GLUTAMATE TRANSPORTER [J].

KANAI, Y ;

HEDIGER, MA .

NATURE, 1992, 360 (6403) :467-471

[7] MECHANISM OF TRANSPORT AND STORAGE OF NEUROTRANSMITTERS [J].

KANNER, BI ;

SCHULDINER, S .

CRC CRITICAL REVIEWS IN BIOCHEMISTRY, 1987, 22 (01) :1-38

[8] MOUSE EXCITATORY AMINO-ACID TRANSPORTER EAAT2 - ISOLATION, CHARACTERIZATION, AND PROXIMITY TO NEUROEXCITABILITY LOCI ON MOUSE CHROMOSOME-2 [J].

KIRSCHNER, MA ;

COPELAND, NG ;

GILBERT, DJ ;

JENKINS, NA ;

AMARA, SG .

GENOMICS, 1994, 24 (02) :218-224

[9] EFFECT OF NONCOMPETITIVE BLOCKADE OF N-METHYL-D-ASPARTATE RECEPTORS ON THE NEUROCHEMICAL SEQUELAE OF EXPERIMENTAL BRAIN INJURY [J].

MCINTOSH, TK ;

VINK, R ;

SOARES, H ;

HAYES, R ;

SIMON, R .

JOURNAL OF NEUROCHEMISTRY, 1990, 55 (04) :1170-1179

[10] THE WNT-1 (INT-1) PROTOONCOGENE IS REQUIRED FOR DEVELOPMENT OF A LARGE REGION OF THE MOUSE-BRAIN [J].

MCMAHON, AP ;

BRADLEY, A .

CELL, 1990, 62 (06) :1073-1085