Effect of Toll-Like Receptor Agonists on the Formation of Macrophage/Foam Cells upon Acute Peritonitis in Mice

被引：7

作者：

Dushkin, M. I. ^{[1
]}

Kovshik, G. G. ^{[2
]}

机构：

[1] Russian Acad Med Sci, Res Inst Therapy, Siberian Branch, Novosibirsk, Russia

[2] Russian Acad Med Sci, Siberian Branch, Res Inst Physiol, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2013年 / 156卷 / 01期

关键词：

toll-like receptor agonists; macrophage/foam cells; inflammation; FOAM CELLS; INFLAMMATION; EXPRESSION; PPAR; RXR;

D O I：

10.1007/s10517-013-2275-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied effects of zymosan, double-stranded RNA, LPS of E. coli and bacterial CpG DNA, agonists of toll-like receptor TLR2, TLR3, TLR4 and TLR9, respectively, on the formation of macrophage/foam cells 24 h after induction of acute peritonitis. Administration of agonists led to transformation of peritoneal macrophages into foam cells and significant activation of cell biosynthesis and increased the content of triglycerides and cholesterol esters in the absence of LDL and irrespective of the capacity of TLR agonists to stimulate neutrophil infiltration and TNF-alpha production in the peritoneal cavity.

引用

页码：49 / 52

页数：4

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