Tracking the establishment of local endemic populations of an emergent enteric pathogen

被引：104

作者：

Holt, Kathryn E. ^{[1
]}

Tran Vu Thieu Nga ^{[2
]}

Duy Pham Thanh ^{[2
]}

Ha Vinh ^{[2
,3
]}

Kim, Dong Wook ^{[4
,5
]}

My Phan Vu Tra ^{[2
]}

Campbell, James I. ^{[2
,6
]}

Nguyen Van Minh Hoang ^{[2
]}

Nguyen Thanh Vinh ^{[2
]}

Pham Van Minh ^{[2
]}

Cao Thu Thuy ^{[2
]}

Tran Thi Thu Nga ^{[2
]}

Thompson, Corinne ^{[2
]}

Tran Thi Ngoc Dung ^{[2
]}

Nguyen Thi Khanh Nhu ^{[2
]}

Phat Voong Vinh ^{[2
]}

Pham Thi Ngoc Tuyet ^{[7
]}

Hoang Le Phuc ^{[8
]}

Nguyen Thi Nam Lien ^{[9
]}

Bui Duc Phu ^{[9
]}

Nguyen Thi Thuy Ai ^{[10
]}

Nguyen Manh Tien ^{[10
]}

Nguyen Dong ^{[10
]}

Parry, Christopher M. ^{[2
,6
]}

Tran Tinh Hien ^{[2
,6
]}

Farrar, Jeremy J. ^{[2
,6
]}

Parkhill, Julian ^{[11
]}

Dougan, Gordon ^{[11
]}

Thomson, Nicholas R. ^{[11
]}

Baker, Stephen ^{[2
,6
,12
]}

机构：

[1] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia

[2] Univ Oxford, Wellcome Trust Major Overseas Programme, Hosp Trop Dis, Clin Res Unit, Ho Chi Minh City, Vietnam

[3] Hosp Trop Dis, Ho Chi Minh City, Vietnam

[4] Int Vaccine Inst, Seoul 151919, South Korea

[5] Hanyang Univ, Coll Pharm, Dept Pharm, Kyeonggi Do 426791, South Korea

[6] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford OX3 7BN, England

[7] Childrens Hosp 2, Ho Chi Minh City, Vietnam

[8] Childrens Hosp 1, Ho Chi Minh City, Vietnam

[9] Hue Cent Hosp, Hue, Thua Thien Hue, Vietnam

[10] Khanh Hoa Gen Hosp, Nha Trang, Vietnam

[11] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[12] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 43期

基金：

新加坡国家研究基金会; 英国医学研究理事会; 英国惠康基金;

关键词：

enteric disease; drug resistance; phylogeography; genomics; SHIGELLA-SONNEI; ESCHERICHIA-COLI; QUINOLONE RESISTANCE; RAST SERVER; SALMONELLA; PLASMID; INFECTIONS; PREVALENCE; EVOLUTION; BURDEN;

D O I：

10.1073/pnas.1308632110

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.

引用

页码：17522 / 17527

页数：6

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