The Snail Family in Normal and Malignant Haematopoiesis

被引：11
作者：
Carmichael, Catherine L. [1 ]
Haigh, Jody J. [1 ]
机构：
[1] Monash Univ, Australian Ctr Blood Dis, Melbourne, Vic 3004, Australia
来源：
CELLS TISSUES ORGANS | 2017年 / 203卷 / 02期
关键词：
Epithelial-mesenchymal transition; Haematopoiesis; Haematopoietic stem cells; Leukaemia; Snail; EPITHELIAL-MESENCHYMAL TRANSITION; FINGER TRANSCRIPTION FACTOR; ACUTE MYELOID-LEUKEMIA; E-CADHERIN EXPRESSION; CANCER STEM-CELLS; RADIATION-INDUCED APOPTOSIS; NEURAL CREST DEVELOPMENT; REPRESSES E-CADHERIN; NF-KAPPA-B; BREAST-CANCER;
D O I：
10.1159/000448655
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Snail family proteins are key inducers of the epithelial-mesenchynna I transition (EMT), a critical process required for normal embryonic development. They have also been strongly implicated in regulating the EMT-like processes required for tumour cell invasion, migration, and metastasis. Whether these proteins also contribute to normal blood cell development, however, remains to be clearly defined. Increasing evidence supports a role for the Snail family in regulating cell survival, migration, and differentiation within the haematopoietic system, as well as potentially an oncogenic role in the malignant transformation of haematopoietic stem cells. This review will provide a broad overview of the Snail family, including key aspects of their involvement in the regulation and development of solid organ cancer, as well as a discussion on our current understanding of Snail family function during normal and malignant haematopoiesis. (C) 2017 S. Karger AG, Basel
引用
收藏
页码：82 / 98
页数：17
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