Element distribution in the corrosion layer and cytotoxicity of alloy Mg-10Dy during in vitro biodegradation

被引：88

作者：

Yang, Lei ^{[1
]}

Hort, Norbert ^{[1
]}

Laipple, Daniel ^{[1
]}

Hoeche, Daniel ^{[1
]}

Huang, Yuanding ^{[1
]}

Kainer, Karl Ulrich ^{[1
]}

Willumeit, Regine ^{[1
]}

Feyerabend, Frank ^{[1
]}

机构：

[1] Helmholtz Zentrum Geesthacht, Inst Mat Res, D-21502 Geesthacht, Germany

来源：

ACTA BIOMATERIALIA | 2013年 / 9卷 / 10期

关键词：

Mg-10Dy alloy; In vitro corrosion; Element distribution; Cytocompatibility; MAGNESIUM ALLOYS; VIVO CORROSION; HEAT-TREATMENT; RARE-EARTH; ELECTROCHEMICAL-BEHAVIOR; RADIATION SYNOVECTOMY; MAGNETIC-RESONANCE; DYSPROSIUM; PERFORMANCE; SURFACE;

D O I：

10.1016/j.actbio.2012.10.001

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The present work investigates the corrosion behaviour, the element distribution in the corrosion layer and the cytocompatibility of alloy Mg-10Dy. The corrosion experiments were performed in a cell culture medium (CCM) under cell culture conditions close to the in vivo environment. The element distribution on the surface as well as in cross-sections of the corrosion layer was investigated using scanning electron microscopy, energy-dispersive X-ray analysis, X-ray photoelectron spectroscopy and X-ray diffraction. The cytocompatibility of alloy Mg-10Dy with primary human osteoblasts was evaluated by MIT, cell adhesion and live/dead staining tests. The results show that the corrosion layer was enriched in Dy, while the P and Ca content gradually decreased from the surface to the bottom of the corrosion layer. In addition, large amounts of MgCO3-3H(2)O formed in the corrosion layer after 28 days immersion. Both extracts and the Dy-enriched corrosion layer of alloy Mg-10Dy showed no cytotoxicity to primary human osteoblasts. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：8475 / 8487

页数：13

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