Element distribution in the corrosion layer and cytotoxicity of alloy Mg-10Dy during in vitro biodegradation

被引：87

作者：

Yang, Lei ^{[1
]}

Hort, Norbert ^{[1
]}

Laipple, Daniel ^{[1
]}

Hoeche, Daniel ^{[1
]}

Huang, Yuanding ^{[1
]}

Kainer, Karl Ulrich ^{[1
]}

Willumeit, Regine ^{[1
]}

Feyerabend, Frank ^{[1
]}

机构：

[1] Helmholtz Zentrum Geesthacht, Inst Mat Res, D-21502 Geesthacht, Germany

来源：

ACTA BIOMATERIALIA | 2013年 / 9卷 / 10期

关键词：

Mg-10Dy alloy; In vitro corrosion; Element distribution; Cytocompatibility; MAGNESIUM ALLOYS; VIVO CORROSION; HEAT-TREATMENT; RARE-EARTH; ELECTROCHEMICAL-BEHAVIOR; RADIATION SYNOVECTOMY; MAGNETIC-RESONANCE; DYSPROSIUM; PERFORMANCE; SURFACE;

D O I：

10.1016/j.actbio.2012.10.001

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The present work investigates the corrosion behaviour, the element distribution in the corrosion layer and the cytocompatibility of alloy Mg-10Dy. The corrosion experiments were performed in a cell culture medium (CCM) under cell culture conditions close to the in vivo environment. The element distribution on the surface as well as in cross-sections of the corrosion layer was investigated using scanning electron microscopy, energy-dispersive X-ray analysis, X-ray photoelectron spectroscopy and X-ray diffraction. The cytocompatibility of alloy Mg-10Dy with primary human osteoblasts was evaluated by MIT, cell adhesion and live/dead staining tests. The results show that the corrosion layer was enriched in Dy, while the P and Ca content gradually decreased from the surface to the bottom of the corrosion layer. In addition, large amounts of MgCO3-3H(2)O formed in the corrosion layer after 28 days immersion. Both extracts and the Dy-enriched corrosion layer of alloy Mg-10Dy showed no cytotoxicity to primary human osteoblasts. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：8475 / 8487

页数：13

共 48 条

[1]

[Anonymous], MRS P

[2]

[Anonymous], 2009, ISO 10993 52009

[3] On the corrosion of binary magnesium-rare earth alloys [J].

Birbilis, N. ;

Easton, M. A. ;

Sudholz, A. D. ;

Zhu, S. M. ;

Gibson, M. A. .

CORROSION SCIENCE, 2009, 51 (03) :683-689

[4] Lanthanides in magnetic resonance imaging [J].

Bottrill, Melanie ;

Nicholas, Lilian Kwok ;

Long, Nicholas J. .

CHEMICAL SOCIETY REVIEWS, 2006, 35 (06) :557-571

[5] Effect of heat treatment on corrosion and electrochemical behaviour of Mg-3Nd-0.2Zn-0.4Zr (wt.%) alloy [J].

Chang, Jian-Wei ;

Guo, Xing-Wu ;

Fu, Peng-Huai ;

Peng, Li-Ming ;

Ding, Wen-Jiang .

ELECTROCHIMICA ACTA, 2007, 52 (09) :3160-3167

[6] Single-Phase Dy2O3:Tb3+ Nanocrystals as Dual-Modal Contrast Agent for High Field Magnetic Resonance and Optical Imaging [J].

Das, Gautom Kumar ;

Zhang, Yan ;

D'Silva, Loyola ;

Padmanabhan, Parasuraman ;

Heng, Boon Chin ;

Loo, Joachim Say Chye ;

Selvan, Subramanian Tamil ;

Bhakoo, Kishore K. ;

Tan, Timothy Thatt Yang .

CHEMISTRY OF MATERIALS, 2011, 23 (09) :2439-2446

[7]

EDMONDS J, 1994, BRIT J RHEUMATOL, V33, P947

[8] Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines [J].

Feyerabend, Frank ;

Fischer, Janine ;

Holtz, Jakob ;

Witte, Frank ;

Willumeit, Regine ;

Druecker, Heiko ;

Vogt, Carla ;

Hort, Norbert .

ACTA BIOMATERIALIA, 2010, 6 (05) :1834-1842

[9] Interference of magnesium corrosion with tetrazolium-based cytotoxicity assays [J].

Fischer, Janine ;

Prosenc, Marc H. ;

Wolff, Martin ;

Hort, Norbert ;

Willumeit, Regine ;

Feyerabend, Frank .

ACTA BIOMATERIALIA, 2010, 6 (05) :1813-1823

[10] Effects of dysprosium on the species-defined microbial microcosm [J].

Fuma, S ;

Takeda, H ;

Takaku, Y ;

Hisamatsu, S ;

Kawabata, Z .

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2005, 74 (02) :263-272

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