Obstructive sleep apnea as a risk factor for silent cerebral infarction

被引:69
作者
Cho, Eo Rin [1 ]
Kim, Hyun [1 ,2 ]
Seo, Hyung Suk [3 ]
Suh, Sooyeon [1 ]
Lee, Seung Ku [1 ]
Shin, Chol [1 ,4 ]
机构
[1] Korea Univ, Coll Med, Inst Human Genom Study, Seoul 136705, South Korea
[2] Korea Univ, Coll Med, Brain Korea Program Biomed Sci 21, Seoul 136705, South Korea
[3] Korea Univ, Dept Radiol, Ansan Hosp, Ansan 425707, Gyeonggi Do, South Korea
[4] Korea Univ, Div Resp & Crit Care Med, Dept Internal Med, Ansan Hosp, Ansan 425707, Gyeonggi Do, South Korea
关键词
basal ganglia; lacunar infarction; obstructive sleep apnea; risk factors; silent cerebral infarction; stroke; BRAIN INFARCTION; ISCHEMIC-STROKE; PREVALENCE; DISEASE; POPULATION;
D O I
10.1111/jsr.12034
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Previous studies have suggested that obstructive sleep apnea (OSA) may be a risk factor for stroke. In this study, we assessed that OSA is an independent risk factor of silent cerebral infarction (SCI) in the general population, and in a non-obese population. This study recruited a total of 746 participants (252 men and 494 women) aged 50-79 years as part of the Korean Genome and Epidemiology Study (KoGES); they underwent polysomnography, brain magnetic resonance imaging and health screening examinations. SCI was assessed by subtypes and brain regions, and lacunar infarction represented lesions <15 mm in size in the penetrating arteries. Moderate-severe OSA was determined by apnea-hypopnea index >= 15. The results indicated that 12.06% had moderate-severe OSA, 7.64% of participants had SCI and 4.96% had lacunar infarction. Moderate-severe OSA was associated positively with SCI [odds ratio (OR): 2.44, 95% confidence interval (CI): 1.03-5.80] and lacunar infarction (OR: 3.48, 95% CI: 1.31-9.23) in the age >= 65-year group compared with those with non-OSA. Additionally, in the basal ganglia, OSA was associated with an increase in the odds for SCI and lacunar infarction in all age groups, and especially in the >= 65-year age group. In the non-obese participants, OSA was also associated positively with SCI in the >= 65-year age group, lacunar infarction in all age groups, and especially in the >= 65-year age group. There was also a positive association with the basal ganglia. Moderate-severe OSA was associated positively with SCI and lacunar infarction in elderly participants. Treatment of OSA may reduce new first-time cerebrovascular events and recurrences.
引用
收藏
页码:452 / 458
页数:7
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