Androgens in women Hormone-modulating therapies for skin disease

被引：34
作者：
Azarchi, Sarah [1 ]
Bienenfeld, Amanda [1 ]
Lo Sicco, Kristen [2 ]
Marchbein, Shari [2 ]
Shapiro, Jerry [2 ]
Nagler, Arielle R. [2 ]
机构：
[1] NYU, Sch Med, New York, NY USA
[2] NYU, Sch Med, Ronald O Perelman Dept Dermatol, 240 E 38th St,12th Fl, New York, NY 10016 USA
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2019年 / 80卷 / 06期
关键词：
acne; androgenetic alopecia; androgen receptor; androgens; combined oral contraceptive; congenital adrenal hyperplasia; dutasteride; female pattern hair loss; finasteride; flutamide; hirsutism; polycystic ovary syndrome; spironolactone; 20; MU-G; POLYCYSTIC-OVARY-SYNDROME; LOW-DOSE FLUTAMIDE; PATTERN HAIR LOSS; ACETATE-ESTROGEN REGIMENS; LONG-TERM TREATMENT; ACNE-VULGARIS; ETHINYL ESTRADIOL; ORAL SPIRONOLACTONE; DOUBLE-BLIND;
D O I：
10.1016/j.jaad.2018.08.061
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Androgen-mediated cutaneous disorders (AMCDs) in women, including acne, hirsutism, and female pattern hair loss, can be treated with hormone-modulating therapies. In the second article in this Continuing Medical Education series, we discuss the hormone-modulating therapies available to dermatologists for the treatment of AMCDs, including combined oral contraceptives, spironolactone, finasteride, dutasteride, and flutamide. Available hormone-modulating treatments used for each AMCDs are reviewed, along with mechanisms of androgen modulation, safety profile, contraindications, monitoring parameters, and evidence of efficacy. Medications discussed include those that are approved by the US Food and Drug Administration for certain AMCDs and some that are used off-label. Despite the ubiquity of hormone-modulating therapies used for AMCDs, this review highlights the need for more rigorous studies to evaluate these therapies for acne, hirsutism, and female pattern hair loss.
引用
收藏
页码：1509 / 1521
页数：13
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