Synthesis, structure, and cytotoxicity of O-[3-(5-tetrazolyl)propyl]oximes

被引：3

作者：

Rubina, K. ^{[1
]}

Abele, E. ^{[1
]}

Belyakov, S. ^{[1
]}

Shestakova, I. ^{[1
]}

Popelis, Yu. ^{[1
]}

机构：

[1] Latvian Inst Organ Chem, LV-1006 Riga, Latvia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 42卷 / 05期

关键词：

D O I：

10.1134/S1070428006050149

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A two-stage method was developed for the conversion of phenyl- and pyridylaldoximes and ketoximes into the corresponding O-[3-(5-tetrazolyl)propyl]oximes. The structure of the sodium salt of 2-acetylpyridine O-[3-(5-tetrazolyl)propyl]oxime was established X-ray diffraction analysis. This compound was shown to possess a high cytotoxic activity in vitro.

引用

页码：735 / 738

页数：4

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