Idiosyncratic Drug-Induced Acute Liver Failure: A Challenging and Distressing Scenario

被引：9

作者：

Colaci, Carla Stefania ^{[1
]}

Mendizabal, Manuel ^{[1
,2
]}

Bessone, Fernando ^{[3
]}

机构：

[1] Hosp Univ Austral, Hepatol & Liver Transplant Unit, Buenos Aires, DF, Argentina

[2] LALREAN, Buenos Aires, DF, Argentina

[3] Univ Rosario, Sch Med, Hosp Provincial Centenario, Rosario, Santa Fe, Argentina

来源：

CURRENT DRUG SAFETY | 2019年 / 14卷 / 02期

关键词：

Hepatotoxicity; acute liver failure; liver transplant; drug hepatotoxicity; Drug-induced liver injury; hepatitis; WILSON-DISEASE; INJURY; DIAGNOSIS; ASSOCIATION; MANAGEMENT; OUTCOMES; TRANSPLANTATION; POPULATION; SPECTRUM; FEATURES;

D O I：

10.2174/1574886314666190215115434

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Idiosyncratic Drug Induced Liver Injury (DILI) is a rare adverse event to drugs that occasionally leads to severe liver damage, being one of the leading causes of Acute Liver Failure (ALF) in developed countries. DILI is largely a diagnosis of exclusion. Discussion and Conclusion: Careful history of drug taking and ruling out other competing etiologies is mandatory given that DILI can present with an extremely variable phenotype. Several prognostic scores have been developed to promptly identify patients with potential risk of developing ALF. New biomarkers to diagnose and predict DILI evolution are under study and hopefully we will benefit from these novel tools in the near future.

引用

页码：94 / 101

页数：8

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