Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments

被引：19

作者：

Ammendola, Mario ^{[1
,2
,3
]}

Haponska, Monika ^{[2
,4
]}

Balik, Karolina ^{[2
,5
]}

Modrakowska, Paulina ^{[2
,5
]}

Matulewicz, Karolina ^{[2
,5
]}

Kazmierski, Lukasz ^{[2
,5
]}

Lis, Aleksandra ^{[5
]}

Kozlowska, Justyna ^{[6
]}

Garcia-Valls, Ricard ^{[1
,2
,4
]}

Giamberini, Marta ^{[1
]}

Bajek, Anna ^{[5
]}

Tylkowski, Bartosz ^{[2
,4
]}

机构：

[1] Univ Rovira & Virgili, Dept Engn Quim, Ave Paisos Catalans 26, Tarragona 43007, Spain

[2] Ctr Tecnol Quim Catalunya, Carrer Marcelli Domingo S-N, Tarragona 43007, Spain

[3] Procter & Gamble Serv Co Nv, Temselaan 100, B-1853 Strombeek Bever, Belgium

[4] Eurecat, Ctr Tecnol Catalunya, C Marcelli Domingo S-N, Tarragona 43007, Spain

[5] Nicolaus Copernicus Univ, Dept Tissue Engn, Ludwik Rydygier Coll Med, Torun, Poland

[6] Nicolas Copernicus Univ Torun, Dept Chem Biomat & Cosmet, Fac Chem, Gagarina 7, PL-87100 Torun, Poland

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

ANTIOXIDANT ACTIVITY; IN-VITRO; POLYPHENOLS; TEMPERATURE; MECHANISMS; PREVENTION; CHITOSAN;

D O I：

10.1038/s41598-020-63444-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a method for delivering biologically active compounds isolated from the Cistus herb. Effects of sterilization and encapsulation on the polyphenol and flavonoid content of Cistus extract were investigated to optimize the production process. Furthermore, in vitro studies were carried out to examine the anticancer properties of sterilized polyphenols and flavonoids on glioblastoma cells isolated from oncological patients. Acquired results show high anticancer potential towards glioblastoma as well as low cytotoxicity towards non-cancer cell lines by the substances in question. Steam sterilization is shown to affect the content of biologically active compounds the least. We demonstrate that the investigated form of drug encapsulation is both efficient and potentially possible to scale up from the viewpoint of the pharmaceutical industry.

引用

页数：10

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