Synthesis of new 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antimicrobial agents

被引：4
|
作者：
Malladi, Shridhar [1 ]
Isloor, Arun M. [1 ]
Peethambar, S. K. [2 ]
Fun, Hoong Kun [3 ,4 ]
机构：
[1] Natl Inst Technol Karnataka, Dept Chem, Med Chem Lab, Mangalore 575025, India
[2] Kuvempu Univ, Dept Biochem, Shankaraghatta 577451, Karnataka, India
[3] Univ Sains Malaysia, Xray Crystallog Unit, Sch Phys, Georgetown 11800, Penang, Malaysia
[4] King Saud Univ, Coll Pharm, Deparment Pharmaceut Chem, Riyadh 11451, Saudi Arabia
来源：
MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 06期
关键词：
Claisen-Schmidt reaction; Pyrazolic chalcones; Pyrazolines; Antimicrobial; ANTITUMOR;
D O I：
10.1007/s00044-012-0267-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New (E)-1-aryl-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones 6 (pyrazolic chalcones) were synthesized from Claisen-Schmidt reaction of 3-aryl-1-phenylpyrazol-4-carboxaldehydes 4 with several acetophenone derivatives 5. Subsequently, the cyclocondensation reaction of chalcones 6 with phenylhydrazine in acetic acid medium afforded the new 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazoles 7. The synthesized compounds were characterized by spectral studies and evaluated for their in vitro antibacterial activity against three pathogenic bacterial strains, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and in vitro antifungal activity against three pathogenic fungal strains Aspergillus flavus, Chrysosporium keratinophilum, and Candida albicans.
引用
收藏
页码：2654 / 2664
页数：11
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