Prediabetes versus type 2 diabetes in patients with acute myocardial infarction and current smoking

被引:0
作者
Kim, Yong Hoon [1 ,5 ]
Her, Ae-Young [1 ]
Jeong, Myung Ho [2 ]
Kim, Byeong-Keuk [3 ]
Hong, Sung-Jin [3 ]
Kim, Seunghwan [4 ]
Ahn, Chul-Min [3 ]
Kim, Jung -Sun [3 ]
Ko, Young-Guk [3 ]
Choi, Donghoon [3 ]
Hong, Myeong-Ki [3 ]
Jang, Yangsoo [3 ]
机构
[1] Kangwon Natl Univ, Dept Internal Med, Div Cardiol, Sch Med, Chunchon, South Korea
[2] Chonnam Natl Univ Hosp, Cardiovasc Ctr, Dept Cardiol, Gwangju, South Korea
[3] Yonsei Univ, Div Cardiol Severance Cardiovasc Hosp, Coll Med, Seoul, South Korea
[4] Inje Univ, Haeundae Paik Hosp, Div Cardiol, Coll Med, Busan, South Korea
[5] Kangwon Natl Univ, Dept Internal Med, Div Cardiol, Sch Med, 156 Baengnyeong Rd, Chunchon 24289, Gangwon, South Korea
关键词
Diabetes; myocardial infarction; prediabetes; smoking; PERCUTANEOUS CORONARY INTERVENTION; CARDIOVASCULAR EVENTS; INSULIN-RESISTANCE; HEART-DISEASE; MORTALITY; CESSATION; RISK; METAANALYSIS; DYSFUNCTION; ADMISSION;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Smoking is linked with increased risk of cardiovascular events among diabetic patients. Prediabetes is associ-ated with increased risk for microvascular and macrovascular complications. We compared the 2-year clinical outcomes of current smoking between prediabetic and type 2 diabetes mellitus (T2DM) patients with acute myocardial infarction (AMI) after newer-generation drug-eluting stent (DES) implantation.Methods: A total of 5161 AMI patients who were currently smoking were classified into normoglycemia (group A: 1,416), prediabetes (group B: 1,740), and T2DM (group C: 2,005) groups. The primary endpoint was major adverse cardiac events (MACEs), defined as all-cause death, recurrent myocardial infarction and any repeat revascularization. The secondary end-point was the occurrence of stent thrombosis (ST) and stroke.Results: The cumulative incidences of all primary and secondary endpoints including MACEs (adjusted hazard ratio [aHR]: 1.150; 95% confidence interval [CI]: 0.891-1.484; P = 0.284), ST, and stroke were similar between group B and group C. The cumulative incidences of MACEs (aHR: 1.385; 95% CI: 1.007-1.904; P = 0.045) and all-cause death or MI were significantly higher in group B than in group A. The cumulative incidences of MACEs (aHR: 1.572; 95% CI: 1.157-2.137; P = 0.004), all-cause death, Re-MI, and all-cause death or MI were significantly higher in group C than in group A.Conclusions: Current smoking leads to worse clinical outcomes in patients with AMI and prediabetes, and thus, similarly to T2DM patients, more attention and more intensive treatment strategy including quitting smoking would be advantageous.
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收藏
页码:612 / 623
页数:12
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