Fibrosis and Adipose Tissue Dysfunction

被引：716

作者：

Sun, Kai ^{[1
]}

Tordjman, Joan ^{[3
,4
,5
]}

Clement, Karine ^{[3
,4
,5
]}

Scherer, Philipp E. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

[3] Hop La Pitie Salpetriere, Inst Cardiometab & Nutr, F-75013 Paris, France

[4] INSERM, U872, Paris, France

[5] Univ Paris 06, FR-75013 Paris, France

来源：

CELL METABOLISM | 2013年 / 18卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Y GASTRIC BYPASS; EXTRACELLULAR-MATRIX; INSULIN-RESISTANCE; BLOOD-FLOW; ENERGY-EXPENDITURE; BARIATRIC SURGERY; LIPID-METABOLISM; OBESE SUBJECTS; WEIGHT-LOSS; MAST-CELLS;

D O I：

10.1016/j.cmet.2013.06.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1 alpha that in turn leads to a potent profibrotic transcriptional program. The pathophysiological impact of adipose tissue fibrosis is likely to play an equally important role on systemic metabolic alterations as fibrotic conditions play in the liver, heart, and kidney. Here, we discuss recent advances in our understanding of the genesis, modulation, and systemic impact of excessive extracellular matrix (ECM) accumulation in adipose tissue of both rodents and humans and the ensuing impact on metabolic dysfunction.

引用

页码：470 / 477

页数：8

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