Applications of next-generation sequencing technologies in functional genomics

被引：800

作者：

Morozova, Olena ^{[1
]}

Marra, Marco A. ^{[1
]}

机构：

[1] BC Canc Agcy Genome Sci Ctr, Vancouver, BC V5Z 4S6, Canada

来源：

GENOMICS | 2008年 / 92卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Illumina/Solexa; ABI/SOLiD; 454/Roche; Functional genomics; Next-generation sequencing technology; Transcriptome; Epigenome; Deep sequencing; Sequencing by synthesis; Sequencing by ligation;

D O I：

10.1016/j.ygeno.2008.07.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new generation of sequencing technologies, from Illumina/Solexa, ABI/SOLiD, 454/Roche, and Helicos, has provided unprecedented opportunities for high-throughput functional genomic research. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted resequencing, discovery of transcription factor binding sites, and noncoding RNA expression profiling. This review discusses applications of next-generation sequencing technologies in functional genomics research and highlights the transforming potential these technologies offer. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：255 / 264

页数：10

共 111 条

[71] From cytogenetics to next-generation sequencing technologies: advances in the detection of genome rearrangements in tumors [J].

Morozova, Olena ;

Marra, Marco A. .

BIOCHEMISTRY AND CELL BIOLOGY, 2008, 86 (02) :81-91

[72] Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1 [J].

Nagel, Stefan ;

Scherr, Michaela ;

Kel, Alexander ;

Hornischer, Klaus ;

Crawford, Gregory E. ;

Kaufmann, Maren ;

Meyer, Corinna ;

Drexler, Hans G. ;

MacLeod, Roderick A. F. .

CANCER RESEARCH, 2007, 67 (04) :1461-1471

[73] Microarray analysis: basic strategies for successful experiments [J].

Ness, Scott A. .

MOLECULAR BIOTECHNOLOGY, 2007, 36 (03) :205-219

[74] Multiplex sequencing of paired-end ditags (MS-PET): a strategy for the ultra-high-throughput analysis of transcriptomes and genomes [J].

Ng, Patrick ;

Tan, Jack J. S. ;

Ooi, Hong Sain ;

Lee, Yen Ling ;

Chiu, Kuo Ping ;

Fullwood, Melissa J. ;

Srinivasan, Kandhadayar G. ;

Perbost, Clotilde ;

Du, Lei ;

Sung, Wing-Kin ;

Wei, Chia-Lin ;

Ruan, Yijun .

NUCLEIC ACIDS RESEARCH, 2006, 34 (12) :e84

[75] DeepSAGE - digital transcriptomics with high sensitivity, simple experimental protocol and multiplexing of samples [J].

Nielsen, Kare L. ;

Hogh, Annabeth Laursen ;

Emmersen, Jeppe .

NUCLEIC ACIDS RESEARCH, 2006, 34 (19)

[76] SOLID-PHASE DNA MINISEQUENCING BY AN ENZYMATIC LUMINOMETRIC INORGANIC PYROPHOSPHATE DETECTION ASSAY [J].

NYREN, P ;

PETTERSSON, B ;

UHLEN, M .

ANALYTICAL BIOCHEMISTRY, 1993, 208 (01) :171-175

[77] Global gene expression analysis of the shoot apical meristem of maize (Zea mays L.) [J].

Ohtsu, Kazuhiro ;

Smith, Marianne B. ;

Emrich, Scott J. ;

Borsuk, Lisa A. ;

Zhou, Ruilian ;

Chen, Tianle ;

Zhang, Xiaolan ;

Timmermans, Marja C. P. ;

Beck, Jon ;

Buckner, Brent ;

Janick-Buckner, Diane ;

Nettleton, Dan ;

Scanlon, Michael J. ;

Schnable, Patrick S. .

PLANT JOURNAL, 2007, 52 (03) :391-404

[78] A SYSTEM FOR RAPID DNA SEQUENCING WITH FLUORESCENT CHAIN-TERMINATING DIDEOXYNUCLEOTIDES [J].

PROBER, JM ;

TRAINOR, GL ;

DAM, RJ ;

HOBBS, FW ;

ROBERTSON, CW ;

ZAGURSKY, RJ ;

COCUZZA, AJ ;

JENSEN, MA ;

BAUMEISTER, K .

SCIENCE, 1987, 238 (4825) :336-341

[79] A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana [J].

Rajagopalan, Ramya ;

Vaucheret, Herve ;

Trejo, Jerry ;

Bartel, David P. .

GENES & DEVELOPMENT, 2006, 20 (24) :3407-3425

[80] Genome-wide location and function of DNA binding proteins [J].

Ren, B ;

Robert, F ;

Wyrick, JJ ;

Aparicio, O ;

Jennings, EG ;

Simon, I ;

Zeitlinger, J ;

Schreiber, J ;

Hannett, N ;

Kanin, E ;

Volkert, TL ;

Wilson, CJ ;

Bell, SP ;

Young, RA .

SCIENCE, 2000, 290 (5500) :2306-+

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