Applications of next-generation sequencing technologies in functional genomics

被引：800

作者：

Morozova, Olena ^{[1
]}

Marra, Marco A. ^{[1
]}

机构：

[1] BC Canc Agcy Genome Sci Ctr, Vancouver, BC V5Z 4S6, Canada

来源：

GENOMICS | 2008年 / 92卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Illumina/Solexa; ABI/SOLiD; 454/Roche; Functional genomics; Next-generation sequencing technology; Transcriptome; Epigenome; Deep sequencing; Sequencing by synthesis; Sequencing by ligation;

D O I：

10.1016/j.ygeno.2008.07.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new generation of sequencing technologies, from Illumina/Solexa, ABI/SOLiD, 454/Roche, and Helicos, has provided unprecedented opportunities for high-throughput functional genomic research. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted resequencing, discovery of transcription factor binding sites, and noncoding RNA expression profiling. This review discusses applications of next-generation sequencing technologies in functional genomics research and highlights the transforming potential these technologies offer. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：255 / 264

页数：10

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