Feeling of Cold Hands and Feet is a Highly Heritable Phenotype

被引：37

作者：

Hur, Yoon-Mi ^{[1
]}

Chae, Jeong-Ho ^{[2
]}

Chung, Ki Wha ^{[3
]}

Kim, Jung Jin ^{[2
]}

Jeong, Hoe-Uk ^{[1
]}

Kim, Jong Woo ^{[4
]}

Seo, Sung Yum ^{[3
]}

Kim, Kyung Soo ^{[5
]}

机构：

[1] Mokpo Natl Univ, Muan Gun, Jeonnam, South Korea

[2] Catholic Univ Korea, Dept Psychiat, Seoul St Marys Hosp, Seoul, South Korea

[3] Kongju Natl Univ, Dept Biol Sci, Gongju, South Korea

[4] Kyunghee Univ Hosp, Coll Oriental Med, Seoul, South Korea

[5] Catholic Univ Korea, Dept Family Med, Seoul St Marys Hosp, Seoul, South Korea

来源：

TWIN RESEARCH AND HUMAN GENETICS | 2012年 / 15卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

cold hands and feet; genetics; twin; environment; Raynaud's Phenomenon; RAYNAUDS-PHENOMENON; MIGRAINE; DISEASE;

D O I：

10.1375/twin.15.2.166

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The prevalence of the feeling of cold hands and feet (FCHF) is high in the general population but the etiology of FCHF is largely unknown. The aim of the present study was to explore whether the FCHF is heritable. Eight hundred and ninety-four pairs of twins completed a question about FCHF. Tetrachoric correlations for FCHF were .58, .29, .67, .52, and .04 for monozygotic male, dizygotic male, monozygotic female, and dizygotic female twins, respectively. Model-fitting analyses suggested that in the best fitting model, additive genetic and nonshared environmental variance including measurement error were 64% (95% CI: 55%-72%) and 36% (28%-45%), respectively. Sex differences in genetic and environmental influences were not significant.

引用

页码：166 / 169

页数：4

共 18 条

[1] FACTOR-ANALYSIS AND AIC [J].

AKAIKE, H .

PSYCHOMETRIKA, 1987, 52 (03) :317-332

[2]

Boin F, 2005, CURR OPIN RHEUMATOL, V17, P752

[3]

Cherkas LF, 2003, J RHEUMATOL, V30, P720

[4] Mechanisms of Raynaud's disease [J].

Cooke, JP ;

Marshall, JM .

VASCULAR MEDICINE, 2005, 10 (04) :293-307

[5]

Eysenck H.J., 1993, Eysenck personality questionnairerevised (EPQR) Database record, DOI [DOI 10.1037/T05461-000, 10.1037/t05461-000]

[6] Familial aggregation of primary Raynaud's disease [J].

Freedman, RR ;

Mayes, MD .

ARTHRITIS AND RHEUMATISM, 1996, 39 (07) :1189-1191

[7]

Gayraud Martine, 2007, Joint Bone Spine, V74, pe1, DOI 10.1016/j.jbspin.2006.07.002

[8] The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine [J].

Hottenga, JJ ;

Vanmolkot, KRJ ;

Kors, EE ;

Kia, SK ;

de Jong, PTVM ;

Haan, J ;

Terwindt, GM ;

Frants, RR ;

Ferrari, MD ;

van den Maagdenberg, AMJM .

CEPHALALGIA, 2005, 25 (12) :1168-1172

[9] Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins [J].

Hur, Y-M ;

Kaprio, J. ;

Iacono, W. G. ;

Boomsma, D. I. ;

McGgue, M. ;

Silventoinen, K. ;

Martin, N. G. ;

Luciano, M. ;

Visscher, P. M. ;

Rose, R. J. ;

He, M. ;

Ando, J. ;

Ooki, S. ;

Nonaka, K. ;

Lin, C. C. H. ;

Lajunen, H. R. ;

Cornes, B. K. ;

Bartels, M. ;

van Beijsterveldt, C. E. M. ;

Cherny, S. S. ;

Mitchell, K. .

INTERNATIONAL JOURNAL OF OBESITY, 2008, 32 (10) :1455-1467

[10] Changes in twinning rates in South Korea: 1981-2002 [J].

Hur, YM ;

Kwon, JS .

TWIN RESEARCH AND HUMAN GENETICS, 2005, 8 (01) :76-79

← 1 2 →