Paroxetine toxicity in a newborn after in utero exposure - Clinical symptoms correlate with serum levels

被引：19

作者：

Knoppert, DC

Nimkar, R

Principi, T

Yuen, D

机构：

[1] St Josephs Hosp, Dept Pharm, London, ON N6 A4V2, Canada

[2] Univ Western Ontario, Dept Paediat, London, ON N6A 3K7, Canada

来源：

THERAPEUTIC DRUG MONITORING | 2006年 / 28卷 / 01期

关键词：

paroxetine; SSRI; newborn; in utero exposure;

D O I：

10.1097/01.ftd.0000187971.95000.25

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

There are several case reports and case series that have examined the acute effects of selective scrotonin reuptake inhibitors (SSRIs) on the newborn. There is considerable controversy whether the reported symptoms represent withdrawal from the SSRI or toxicity caused by the SSRI. A case of an infant who was exposed to paroxetine during pregnancy is presented. This case supports the notion of serotonin toxicity and is believed to be the first report that substantiates clinical symptoms with serum levels of the offending SSRI.

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收藏

页码：5 / 7

页数：3

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