Phase and absorption retrieval using incoherent X-ray sources

被引:119
作者
Munro, Peter R. T. [1 ]
Ignatyev, Konstantin [1 ]
Speller, Robert D. [1 ]
Olivo, Alessandro [1 ]
机构
[1] UCL, Dept Med Phys & Bioengn, London WC1E 6BT, England
基金
英国工程与自然科学研究理事会; 澳大利亚研究理事会; 英国惠康基金;
关键词
X-ray imaging; differential phase contrast; SYNCHROTRON-RADIATION; DIGITAL MAMMOGRAPHY; CONTRAST IMAGES; IMAGING-SYSTEMS; FIELD;
D O I
10.1073/pnas.1205396109
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
X-ray phase contrast imaging has overcome the limitations of X-ray absorption imaging in many fields. Particular effort has been directed towards developing phase retrieval methods: These reveal quantitative information about a sample, which is a requirement for performing X-ray phase tomography, allows material identification and better distinction between tissue types, etc. Phase retrieval seems impossible with conventional X-ray sources due to their low spatial coherence. In the only previous example where conventional sources have been used, collimators were employed to produce spatially coherent secondary sources. We present a truly incoherent phase retrieval method, which removes the spatial coherence constraints and employs a conventional source without aperturing, collimation, or filtering. This is possible because our technique, based on the pixel edge illumination principle, is neither interferometric nor crystal based. Beams created by an X-ray mask to image the sample are smeared due to the incoherence of the source, yet we show that their displacements can still be measured accurately, obtaining strong phase contrast. Quantitative information is extracted from only two images rather than a sequence as required by several coherent methods. Our technique makes quantitative phase imaging and phase tomography possible in applications where exposure time and radiation dose are critical. The technique employs masks which are currently commercially available with linear dimensions in the tens of centimeters thus allowing for a large field of view. The technique works at high photon energy and thus promises to deliver much safer quantitative phase imaging and phase tomography in the future.
引用
收藏
页码:13922 / 13927
页数:6
相关论文
共 30 条
  • [1] DIGITAL MAMMOGRAPHY WITH SYNCHROTRON-RADIATION
    ARFELLI, F
    BRAVIN, A
    BARBIELLINI, G
    CANTATORE, G
    CASTELLI, E
    DIMICHIEL, M
    POROPAT, P
    ROSEI, R
    SESSA, M
    VACCHI, A
    DALLAPALMA, L
    LONGO, R
    BERNSTORFF, S
    SAVOIA, A
    TROMBA, G
    [J]. REVIEW OF SCIENTIFIC INSTRUMENTS, 1995, 66 (02) : 1325 - 1328
  • [2] Clinical mammography at the SYRMEP beam line
    Castelli, E.
    Arfelli, F.
    Dreossi, D.
    Longo, R.
    Rokvic, T.
    Cova, M. A.
    Quaia, E.
    Tonutti, M.
    Zanconati, F.
    Abrami, A.
    Chenda, V.
    Menk, R. H.
    Quai, E.
    Tromba, G.
    Bregant, P.
    de Guarrini, F.
    [J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2007, 572 (01) : 237 - 240
  • [3] Diffraction enhanced x-ray imaging
    Chapman, D
    Thomlinson, W
    Johnston, RE
    Washburn, D
    Pisano, E
    Gmur, N
    Zhong, Z
    Menk, R
    Arfelli, F
    Sayers, D
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (11) : 2015 - 2025
  • [4] Holotomography: Quantitative phase tomography with micrometer resolution using hard synchrotron radiation x rays
    Cloetens, P
    Ludwig, W
    Baruchel, J
    Van Dyck, D
    Van Landuyt, J
    Guigay, JP
    Schlenker, M
    [J]. APPLIED PHYSICS LETTERS, 1999, 75 (19) : 2912 - 2914
  • [5] PHASE-CONTRAST IMAGING OF WEAKLY ABSORBING MATERIALS USING HARD X-RAYS
    DAVIS, TJ
    GAO, D
    GUREYEV, TE
    STEVENSON, AW
    WILKINS, SW
    [J]. NATURE, 1995, 373 (6515) : 595 - 598
  • [6] Refracting Rontgen's rays: Propagation-based x-ray phase contrast for biomedical imaging
    Gureyev, T. E.
    Mayo, S. C.
    Myers, D. E.
    Nesterets, Ya.
    Paganin, D. M.
    Pogany, A.
    Stevenson, A. W.
    Wilkins, S. W.
    [J]. JOURNAL OF APPLIED PHYSICS, 2009, 105 (10)
  • [7] Hard x-ray quantitative non-interferometric phase-contrast microscopy
    Gureyev, TE
    Raven, C
    Snigirev, A
    Snigireva, I
    Wilkins, SW
    [J]. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 1999, 32 (05) : 563 - 567
  • [8] X-RAY INTERACTIONS - PHOTOABSORPTION, SCATTERING, TRANSMISSION, AND REFLECTION AT E=50-30,000 EV, Z=1-92
    HENKE, BL
    GULLIKSON, EM
    DAVIS, JC
    [J]. ATOMIC DATA AND NUCLEAR DATA TABLES, 1993, 54 (02) : 181 - 342
  • [9] Herman G.T., 1980, Image Reconstruction from Projections. The Fundamentals of Computerirzed Tomography
  • [10] Effects of signal diffusion on x-ray phase contrast images
    Ignatyev, K.
    Munro, P. R. T.
    Speller, R. D.
    Olivo, A.
    [J]. REVIEW OF SCIENTIFIC INSTRUMENTS, 2011, 82 (07)