Qualitative screening in doping control by MALDI-TOF/TOF mass spectrometry: A proof-of-evidence

被引：6
作者：
Galano, E. [1 ]
Fidani, M. [3 ,4 ]
Baia, F. [3 ,4 ]
Palomba, L. [5 ]
Marino, G. [1 ,2 ]
Amoresano, A. [1 ,2 ]
机构：
[1] Univ Naples Federico II, Dept Organ Chem & Biochem, I-80126 Naples, Italy
[2] Univ Naples Federico II, Sch Biotechnol Sci, I-80126 Naples, Italy
[3] Unirelab Srl, Milan, Italy
[4] Unirelab Srl, Rome, Italy
[5] Univ Urbino, Dept Biomol Sci, I-61029 Urbino, Italy
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2012年 / 71卷
关键词：
Urine; Cocaine; Drugs; MALDI-TOF/TOF; Nitrocellulose; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; METABOLITES; COCAINE; HAIR;
D O I：
10.1016/j.jpba.2012.08.003
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The analysis of doping agents in biological fluids is of top significance in clinical and forensic toxicology. Herein we describe the study of a screening method for the detection of a mixture of drugs of potential abuse including cocaine and its metabolites. By using matrix-assisted laser desorption/ionization MALDI-TOF/TOF mass spectrometry. This screening procedure to detect the presence of different drugs, avoiding time consuming procedures could be useful in different fields of forensic analytical toxicology, including antidoping analysis. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：193 / 197
页数：5
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