Ruthenium(0)-Catalyzed sp3 C-H Bond Arylation of Benzylic Amines Using Arylboronates

被引：71
|
作者：
Dastbaravardeh, Navid [1 ]
Schnuerch, Michael [1 ]
Mihovilovic, Marko D. [1 ]
机构：
[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 07期
基金：
奥地利科学基金会;
关键词：
ACTIVATION; FUNCTIONALIZATION; MECHANISM; PALLADIUM; AMIDES;
D O I：
10.1021/ol300627p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Ru-catalyzed direct arylation of benzylic sp(3) carbons of acyclic amines with arylboronates is reported. This highly regioselective and efficient transformation can be performed with various combinations of N-(2-pyridyl) substituted benzylamines and arylboronates. Substitution of the pyridine directing group in the 3-position proved to be crucial in order to achieve high arylation yields. Furthermore, the pyridine directing group can be removed in high yields via a two-step protocol.
引用
收藏
页码：1930 / 1933
页数：4
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