Antimycobacterial activity of fractions and isolated compounds from Vetiveria zizanioides

被引：19

作者：

Gupta, Shikha ^{[1
]}

Dwivedi, Gaurav R. ^{[2
]}

Darokar, Mahendra P. ^{[2
]}

Srivastava, Santosh K. ^{[1
]}

机构：

[1] Cent Inst Med & Aromat Plants, Div Analyt Chem, Lucknow 226015, Uttar Pradesh, India

[2] Cent Inst Med & Aromat Plants, Mol Bioprospect Dept, Lucknow 226015, Uttar Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 07期

关键词：

Vetiveria zizanioides; Mycobacterium smegmatis; Drug-resistant strain; Antimycobacterial activity; 5,10-Pentadecadiyn-1-ol; alpha-Curcumene; Hydroxy junipene; OIL; TUBERCULOSIS; CONSTITUENTS;

D O I：

10.1007/s00044-011-9639-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The essential oil of Vetiveria zizanioides showed significant antimycobacterial activity against the drug-resistant strains of Mycobacterium smegmatis, which on activity guided fractionation afforded four bioactive fractions Vz-2, Vz-7, Vz-8, and Vz-9. Further purification of these bioactive fractions over preparative thin layer chromatographic resulted in the characterization of six compounds: 5, 10-pentadecadiyn-1-ol (1), alpha-curcumene (3), hydroxy junipene (4), (+) cycloisosativene (5), valencine (6), and selino 3,7 (11)-diene (7). All these compounds showed significant antimycobacterial activity against the drug-resistant strains (MDR-R and MDR-40) of M. smegmatis and their MIC was in the range of 31.25-62.5 mu g/ml. These results may be of great help in antimycobacterial drug development from a very common, inexpensive, and non toxic natural product.

引用

页码：1283 / 1289

页数：7

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