Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines, in RAW264.7 macrophages

被引：62

作者：

Choi, EM

Hwang, JK

机构：

[1] Yonsei Univ, Dept Biotechnol, Seoul 120749, South Korea

[2] Yonsei Univ, Bioprod Res Ctr, Seoul 120749, South Korea

来源：

FITOTERAPIA | 2005年 / 76卷 / 7-8期

基金：

新加坡国家研究基金会;

关键词：

Morus alba; nitric oxide; prostaglandin; cytokine;

D O I：

10.1016/j.fitote.2005.05.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Morus alba leaf methanolic extract and its fractions (chloroform, butanol, and aqueous fractions) were found to inhibit NO production in LPS-activated RAW264.7 macrophages without an appreciable cytotoxic effect at concentration from 4 to 100 mu g/ml. LPS-induced PGE(2) production was significantly reduced only by butanol fraction. In addition, M. alba leaf extract and its fractions significantly decreased the production of TNF-alpha. These findings suggest that M. alba leaf extract seems to be able in suppressing inflammatory mediators. Moreover, the inhibitory activities on COX-2 and iNOS of its butanol fraction are warranted for further elucidation of active principles for development of new antiinflammatory agents. (c) 2005 Elsevier B.V All rights reserved.

引用

页码：608 / 613

页数：6

共 24 条

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