Macromolecular therapeutics in cancer treatment: The EPR effect and beyond

被引：658
作者：
Maeda, Hiroshi [1 ]
机构：
[1] Sojo Univ, Inst DDS Res, Kumamoto 8600082, Japan
来源：
JOURNAL OF CONTROLLED RELEASE | 2012年 / 164卷 / 02期
关键词：
EPR-effect; SMANCS; Tumor targeting; Heterogeneity of EPR effect; Augmentation of EPR effect; Vascular permeability; TUMOR-TARGETED DELIVERY; POLYMER CONJUGATION; ANTICANCER AGENTS; IMAGE-ENHANCEMENT; HUMAN BREAST; DRUG; CHEMOTHERAPY; NEOCARZINOSTATIN; MECHANISM; CETUXIMAB;
D O I：
10.1016/j.jconrel.2012.04.038
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this review, I have discussed various issues of the cancer drug targeting primarily related to the EPR (enhanced permeability and retention) effect, which utilized nanomedicine or macromolecular drugs. The content goes back to the development of the first polymer-protein conjugate anticancer agent SMANCS and development of the arterial infusion in Lipiodol formulation into the tumor feeding artery (hepatic artery for hepatoma). The brief account on the EPR effect and its definition, factors involved, heterogeneity, and various methods of augmentation of the EPR effect, which showed remarkably improved clinical outcomes are also discussed. Various obstacles involved in drug developments and commercialization are also discussed through my personal experience and recollections. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：138 / 144
页数：7
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