Cancer - beta-catenin as oncogene: The smoking gun

被引：290

作者：

Peifer, M

机构：

[1] Department of Biology, Univ. of N. Carolina at Chapel Hill, Chapel Hill

来源：

SCIENCE | 1997年 / 275卷 / 5307期

关键词：

D O I：

10.1126/science.275.5307.1752

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：1752 / 1753

页数：2

共 16 条

[1] NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion [J].

Barth, AIM ;

Pollack, AL ;

Altschuler, Y ;

Mostov, KE ;

Nelson, WJ .

JOURNAL OF CELL BIOLOGY, 1997, 136 (03) :693-706

[2] Functional interaction of beta-catenin with the transcription factor LEF-1 [J].

Behrens, J ;

vonKries, JP ;

Kuhl, M ;

Bruhn, L ;

Wedlich, D ;

Grosschedl, R ;

Birchmeier, W .

NATURE, 1996, 382 (6592) :638-642

[3] pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila [J].

Brunner, E ;

Peter, O ;

Schweizer, L ;

Basler, K .

NATURE, 1997, 385 (6619) :829-833

[4] Nuclear localization of beta-catenin by interaction with transcription factor LEF-1 [J].

Huber, O ;

Korn, R ;

McLaughlin, J ;

Ohsugi, M ;

Herrmann, BG ;

Kemler, R .

MECHANISMS OF DEVELOPMENT, 1996, 59 (01) :3-10

[5] Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC(-/-) colon carcinoma [J].

Korinek, V ;

Barker, N ;

Morin, PJ ;

vanWichen, D ;

deWeger, R ;

Kinzler, KW ;

Vogelstein, B ;

Clevers, H .

SCIENCE, 1997, 275 (5307) :1784-1787

[6] Signal transduction through beta-catenin and specification of cell fate during embryogenesis [J].

Miller, JR ;

Moon, RT .

GENES & DEVELOPMENT, 1996, 10 (20) :2527-2539

[7] XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos [J].

Molenaar, M ;

vandeWetering, M ;

Oosterwegel, M ;

PetersonMaduro, J ;

Godsave, S ;

Korinek, V ;

Roose, J ;

Destree, O ;

Clevers, H .

CELL, 1996, 86 (03) :391-399

[8] Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC [J].

Morin, PJ ;

Sparks, AB ;

Korinek, V ;

Barker, N ;

Clevers, H ;

Vogelstein, B ;

Kinzler, KW .

SCIENCE, 1997, 275 (5307) :1787-1790

[9]

Munemitsu S, 1996, MOL CELL BIOL, V16, P4088

[10] The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration [J].

Nathke, IS ;

Adams, CL ;

Polakis, P ;

Sellin, JH ;

Nelson, WJ .

JOURNAL OF CELL BIOLOGY, 1996, 134 (01) :165-179

← 1 2 →