Bio- and chemical syntheses of mangiferin and congeners

被引：28

作者：

Ehianeta, Teddy Stephen ^{[1
]}

Laval, Stephane ^{[1
]}

Yu, Biao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

BIOFACTORS | 2016年 / 42卷 / 05期

关键词：

mangiferin; C-glycoside; xanthone; biosynthesis; chemical synthesis; ANEMARRHENA-ASPHODELOIDES BUNGE; NATURALLY-OCCURRING XANTHONES; TETRAOXYGENATED XANTHONES; ANTIOXIDANT ACTIVITY; MEDICINAL PROPERTIES; CANSCORA-DECUSSATA; COLORING MATTER; INDICA LINN; BIOSYNTHESIS; DERIVATIVES;

D O I：

10.1002/biof.1279

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mangiferin (2C-b-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone C-glycoside occurring in many plant species. Composed of a glucose unit C1fi2 linked to a 1,3,6,7-tetrahydroxyxanthone aglycone, mangiferin exhibits a wide range of biological activities, which recently renewed its interest as a potential pharmacophore. Mangiferin is mainly isolated after extraction procedures from natural sources alongside with its isoforms isomangiferin, homomangiferin, and neomangiferin. However, enzymatic and chemical approaches have been developed to access these phytochemicals, which address the challenging construction of the C-glycosidic linkage. In addition, both approaches have been exploited to modify the aglycone and the sugar moiety in order to afford analogues with specific and improved pharmacological activities. Herein, we provide a comprehensive review on the biosynthesis and chemical synthesis of mangiferin and its congeners. (C) 2016 BioFactors.

引用

页码：445 / 458

页数：14

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