Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation

被引：29

作者：

Palanivel, J. A. ^{[1
]}

Macbeth, A. E. ^{[1
]}

Levell, N. J. ^{[1
]}

机构：

[1] Norfolk & Norwich Univ Hosp & NHS Trust, Dept Dermatol, Norwich, Norfolk, England

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2013年 / 38卷 / 01期

关键词：

PATHWAY;

D O I：

10.1111/j.1365-2230.2012.04375.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.

引用

页码：44 / 46

页数：3

共 7 条

[1] Genetic factors in chronic inflammation: Single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population [J].

Ferguson, Lynnette R. ;

Han, Dug Yeo ;

Fraser, Alan G. ;

Huebner, Claudia ;

Lam, Wen Jiun ;

Morgan, Angharad R. ;

Duan, He ;

Karunasinghe, Nishi .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2010, 690 (1-2) :108-115

[2] Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis [J].

Levine, RL ;

Wadleigh, M ;

Cools, J ;

Ebert, BL ;

Wernig, G ;

Huntly, BJP ;

Boggon, TJ ;

Wlodarska, L ;

Clark, JJ ;

Moore, S ;

Adelsperger, J ;

Koo, S ;

Lee, JC ;

Gabriel, S ;

Mercher, T ;

D'Andrea, A ;

Fröhling, S ;

Döhner, K ;

Marynen, P ;

Vandenberghe, P ;

Mesa, RA ;

Tefferi, A ;

Griffin, JD ;

Eck, MJ ;

Sellers, WR ;

Meyerson, M ;

Golub, TR ;

Lee, SJ ;

Gilliland, DG .

CANCER CELL, 2005, 7 (04) :387-397

[3] Targeting myeloproliferative neoplasms with JAK inhibitors [J].

Pardanani, Animesh ;

Tefferi, Ayalew .

CURRENT OPINION IN HEMATOLOGY, 2011, 18 (02) :105-110

[4] The JAK/STAT signaling pathway [J].

Rawlings, JS ;

Rosler, KM ;

Harrison, DA .

JOURNAL OF CELL SCIENCE, 2004, 117 (08) :1281-1283

[5]

ROSS HJ, 1991, CANCER, V68, P441, DOI 10.1002/1097-0142(19910715)68:2<441::AID-CNCR2820680239>3.0.CO

[6]

2-4

[7]

Walker JG, 2005, J RHEUMATOL, V32, P1650

← 1 →