Improved Julia-Kocienski conditions for the methylenation of aldehydes and ketones

被引：60
作者：
Aïssa, C [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 01期
关键词：
D O I：
10.1021/jo051693a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The scope of the methylenation of aldehydes and ketones under optimized Julia-Kocienski conditions is broadened by using 1-tert-butyl-1H-tetrazol-5-ylmethyl sulfone. Two different Barbier-type procedures are applied with NaHMDS at -78 degrees C or Cs2CO3 at 70 degrees C. The latter conditions are also adapted for the preparation of 1,2-disubstituted olefins and intramolecular olefination reactions.
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页码：360 / 363
页数：4
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