Substituted tubaic acids, new oxidative rotenoid metabolites from Lonchocarpus nicou

被引：13

作者：

Lawson, MA

Kaouadji, M

Allais, DP

Champavier, Y

Chulia, AJ

机构：

[1] Fac Sci & Tech, Dept Chim, F-87060 Limoges, France

[2] UPRES EA 1085 Biomol & Cibles Cellulaires Tumoral, Lab Pharmacognosie, Fac Pharm, F-87025 Limoges, France

[3] Univ Limoges, Serv Commun RMN, F-87025 Limoges, France

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 04期

关键词：

Fabaceae; Lonchocarpus nicou; rotoic acid; deguoic acid; opened rotenoids ring-C; seco-rotenoids;

D O I：

10.1016/j.tetlet.2005.11.069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A lipophile extract of Lonchocarpus nicou roots afforded two likely O-substituted isomers of the known tubaic acids. Spectroscopic analysis assigned to the former, named (-)-rotoic acid, the new 4-(2,3-dihydro-6,7-dimethoxychromon-3-oxy) tubaic acid structure which differs from (-)-deguoic acid, the latter, by the beta-tubaic acid part. Biogenetically, the two compounds could be considered as resulting from the parent rotenone and deguelin, respectively, by oxidative ring-C cleavage. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：451 / 454

页数：4

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