Error analysis for PET measurement of dopamine D2 receptor occupancy by antipsychotics with [11C]raclopride and [11C]FLB 457

被引：9

作者：

Ikoma, Yoko ^{[1
,2
]}

Ito, Hiroshi ^{[1
]}

Arakawa, Ryosuke ^{[1
]}

Okumura, Masaki ^{[1
]}

Seki, Chie ^{[1
]}

Shidahara, Miho ^{[1
]}

Takahashi, Hidehiko ^{[1
]}

Kimura, Yuichi ^{[1
]}

Kanno, Iwao ^{[1
]}

Suhara, Tetsuya ^{[1
]}

机构：

[1] Natl Inst Radiol Sci, Mol Imaging Ctr, Inage Ku, Chiba 2638555, Japan

[2] Natl Cardiovasc Ctr, Res Inst, Dept Invest Radiol, Osaka, Japan

来源：

NEUROIMAGE | 2008年 / 42卷 / 04期

基金：

日本学术振兴会;

关键词：

positron emission tomography; dopamine D(2) receptor; occupancy; (11)C]raclopride; (11)C]FLB 457;

D O I：

10.1016/j.neuroimage.2008.05.056

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dopamine D(2) receptor occupancy by antipsychotic drugs has been measured with positron emission tomography (PET) by comparing the binding potential (BP) values before and after drug administration. This occupancy has been found to be related to clinical effects and side effects. in this study, we evaluated the in simulation and human studies of [(11)C]raclopride and for the high affinity ligand [(11)C]FLB 457. Time-activity curves of [(11)C]raclopride and [(11)C]FLB 457 were simulated, and the reliability of BP estimated by a simplified reference tissue model and the calculated Occupancy were investigated for various noise levels, BP values, and scan durations. Then, in the human PET study with and without antipsychotics, the uncertainty of BP and occupancy estimates and the scan duration required for a reliable estimation were investigated by a bootstrap approach. Reliable and unbiased estimates of [(11)C]raclopride BP(ND) could be obtained with recording as short as 32 min, with the relative standard deviation (SD) of the striatal occupancy remaining less than 10%. Conversely, in [(11)C]FLB 457 Studies, the mean value increased and SD of the temporal cortex and thalamus exceeded 10% when the scan duration was shorter than 60 min. These results demonstrated that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely with an optimal scan duration with [(11)C]raclopride and [(11)C]FLB 457. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1285 / 1294

页数：10

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