Predictors of successful closure of patent ductus arteriosus with indomethacin

被引：38

作者：

Ahamed, M. F. ^{[1
]}

Verma, P. ^{[2
]}

Lee, S. ^{[3
]}

Vega, M. ^{[1
]}

Wang, D. ^{[4
]}

Kim, M. ^{[4
]}

Fuloria, M. ^{[1
]}

机构：

[1] Childrens Hosp Montefiore, Albert Einstein Coll Med, Div Neonatal Perinatal Med, Bronx, NY 10461 USA

[2] Brown Univ, Alpert Med Sch, Div Neonatol, Providence, RI 02912 USA

[3] Mt Sinai Hosp, Icahn Sch Med, Div Pediat Cardiol, New York, NY 10029 USA

[4] Albert Einstein Coll Med, Div Biostat, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

来源：

JOURNAL OF PERINATOLOGY | 2015年 / 35卷 / 09期

关键词：

PLATELET COUNT; BIRTH-WEIGHT; RISK-FACTORS; INFANTS; LIFE; THROMBOCYTOPENIA; CONTRIBUTE; IBUPROFEN; CELLS;

D O I：

10.1038/jp.2015.33

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: To determine whether platelet counts can predict the likelihood of successful closure of patent ductus arteriosus (PDA) with indomethacin. STUDY DESIGN: This was a retrospective cohort study of infants <32 weeks' gestational age (GA) and birth weight <1500 g with PDA. Clinical characteristics between infants who achieved ductal closure with indomethacin and those who failed were compared. Multivariable logistic regression was used to identify predictors of successful ductal closure. RESULTS: In infants with hemodynamically significant PDA, older GA (odds ratio = 1.54; 95% confidence interval: 1.12 to 2.13), male gender (odds ratio = 3.02; 95% confidence interval: 1.08 to 8.49) and higher platelet count (odds ratio = 1.5; 95% confidence interval: 1.04 to 2.17) prior to indomethacin treatment were associated with successful ductal closure with indomethacin. CONCLUSION: Older GA, male gender and higher platelet count at time of treatment of hemodynamically significant PDA are predictors of successful ductal closure with indomethacin.

引用

页码：729 / 734

页数：6

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