Antitumour Activities of Sesquiterpene Lactones from Inula helenium and Inula japonica

被引：0

作者：

Li, Yong ^{[2
,4
]}

Ni, Zhi-Yu ^{[4
]}

Zhu, Meng-Chu ^{[3
]}

Dong, Mei ^{[4
]}

Wang, Si-Ming ^{[3
]}

Shi, Qing-Wen ^{[1
]}

Zhang, Man-Li ^{[1
]}

Wang, Yu-Fang ^{[1
]}

Huo, Chang-hong ^{[1
]}

Kiyota, Hiromasa ^{[5
]}

Cong, Bin ^{[4
]}

机构：

[1] Hebei Med Univ, Sch Pharmaceut Sci, Dept Med Nat Prod Chem, Shijiazhuang 050017, Hebei Prov, Peoples R China

[2] Hebei Med Univ, Hosp 4, Dept Thorac, Shijiazhuang 050011, Hebei Province, Peoples R China

[3] Jiangsu Univ, Lab Med Sci, Sch Med Sci & Lab Med, Zhenjing 212013, Jiangsu, Peoples R China

[4] Hebei Med Univ, Hebei Key Lab Forens Med, Dept Forens Med, Shijiazhuang 050017, Hebei Province, Peoples R China

[5] Tohoku Univ, Grad Sch Agr Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2012年 / 67卷 / 7-8期

基金：

中国国家自然科学基金; 日本学术振兴会;

关键词：

Inula sp; Sesquiterpenes; Antitumour Activity; CONSTITUENTS; EXTRACTION; CANCER;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 <= 100 mu m). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an alpha-exomethylene-gamma-lactone ring is necessary for these activities.

引用

页码：375 / 380

页数：6

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