Microfluidic-based synthesis of non-spherical magnetic hydrogel microparticles

被引：190
作者：
Hwang, Dae Kun [1 ]
Dendukuri, Dhananjay [1 ]
Doyle, Patrick S. [1 ]
机构：
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
来源：
LAB ON A CHIP | 2008年 / 8卷 / 10期
基金：
加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1039/b805176c
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Spherical and non-spherical magnetic hydrogel particles were synthesized in a microfluidic device containing an embedded UV light reflector. Monodisperse magnetic emulsion droplets were generated in a T-junction and allowed to relax into spheres, disks, and plugs in confining microchannel geometries. Particle morphology was locked-in via UV-initiated photopolymerization. The role of the reflector in the microchannel is to provide a uniform distribution of UV energy to the magnetic emulsion droplets and to increase the UV flux, which significantly improves UV polymerization conditions for microfluidic-based particle synthesis. Magnetic nanoparticles were uniformly encapsulated in the hydrogel, giving the microparticles superparamagnetic behavior. Additionally, the non-spherical particles show anisotropic responses under an applied external magnetic field.
引用
收藏
页码：1640 / 1647
页数：8
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