Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease

被引：95

作者：

Chiang, Chih-Chao ^{[1
,2
]}

Korinek, Michal ^{[3
,4
,5
,6
]}

Cheng, Wei-Jen ^{[1
,7
,8
]}

Hwang, Tsong-Long ^{[3
,4
,5
,7
,9
,10
]}

机构：

[1] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Taoyuan, Taiwan

[2] Puxin Fengze Chinese Med Clin, Taoyuan, Taiwan

[3] Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan, Taiwan

[4] Chang Gung Univ Sci & Technol, Res Ctr Chinese Herbal Med, Res Ctr Food & Cosmet Safety, Taoyuan, Taiwan

[5] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Taoyuan, Taiwan

[6] Kaohsiung Med Univ, Coll Life Sci, Dept Biotechnol, Kaohsiung, Taiwan

[7] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan, Taiwan

[8] Chang Gung Mem Hosp, Ctr Tradit Chinese Med, Taoyuan, Taiwan

[9] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan, Taiwan

[10] Ming Chi Univ Technol, Dept Chem Engn, New Taipei, Taiwan

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

关键词：

coronavirus disease 2019; severe acute respiratory syndrome coronavirus 2; acute respiratory distress syndrome; neutrophils; neutrophil extracellular trap; ACUTE LUNG INJURY; N-ACETYLCYSTEINE; CLINICAL CHARACTERISTICS; ELASTASE INHIBITOR; EXTRACELLULAR TRAPS; ANTAGONIST; IDENTIFICATION; PNEUMONIA; PROTEINS; COVID-19;

D O I：

10.3389/fphar.2020.572009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review describes targeting neutrophils as a potential therapeutic strategy for acute respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID-19), a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutrophil counts are significantly elevated in patients with COVID-19 and significantly correlated with disease severity. The neutrophil-to-lymphocyte ratio can serve as a clinical marker for predicting fatal complications related to ARDS in patients with COVID-19. Neutrophil-associated inflammation plays a critical pathogenic role in ARDS. The effector functions of neutrophils, acting as respiratory burst oxidants, granule proteases, and neutrophil extracellular traps, are linked to the pathogenesis of ARDS. Hence, neutrophils can not only be used as pathogenic markers but also as candidate drug targets for COVID-19 associated ARDS.

引用

页数：14

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