Recent Advances in SPE-Chiral-HPLC Methods for Enantiomeric Separation of Chiral Drugs in Biological Samples

被引：37

作者：

Ali, Imran ^{[1
]}

Alam, Syed Dilshad ^{[1
]}

Al-Othman, Zeid A. ^{[2
]}

Farooqi, Javed A. ^{[3
]}

机构：

[1] Jamia Millia Islamia Cent Univ Jamia Nagar, Dept Chem, New Delhi 110025, India

[2] King Saud Univ, Dept Chem, Coll Sci, Riyadh 11451, Saudi Arabia

[3] Indira Gandhi Natl Open Univ, Dept Chem, Sch Sci, New Delhi 110068, India

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 2013年 / 51卷 / 07期

关键词：

SOLID-PHASE EXTRACTION; LIQUID-CHROMATOGRAPHIC ANALYSIS; BETA-ADRENERGIC BLOCKERS; TANDEM MASS-SPECTROMETRY; DUAL-COLUMN EXTRACTION; HUMAN PLASMA; HUMAN SERUM; ENANTIOSELECTIVE DETERMINATION; STATIONARY-PHASE; STEREOSELECTIVE DETERMINATION;

D O I：

10.1093/chromsci/bms262

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In medical practices, the determination of enantiomeric ratio of the chiral drugs is very important for their activities, bioavailabilities and biodegradation. Only homochiral medication is safe for humans. The chiral analysis in biological samples is the first and most important step. The present article describes the technical strategies of the enantiomeric resolution of racemic drugs in biological samples. Attempts have been made to describe sample preparation by solid-phase extraction and enantiomeric resolution by chiral high-performance liquid chromatography. Various chiral stationary phases used in chiral separations of racemic drugs have been described. Efforts are also made to discuss the chiral recognition mechanism and future perspectives of chiral analyses in biological samples.

引用

页码：645 / 654

页数：10

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