Mannich reaction as a new route to pyridine-based polyaminocarboxylic ligands

被引：17

作者：

Aime, S

Cavallotti, C

Gianolio, E

Giovenzana, GB

Palmisano, G

Sisti, M

机构：

[1] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

[2] Univ Turin, Dipartimento Chim, IFM, I-10125 Turin, Italy

[3] Univ Piemonte Orientale A Avogadro, Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 08期

关键词：

D O I：

10.1021/ol036510q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The Mannich reaction was successfully employed to obtain two pyridine-based ligands 1 and 2. The latter represents the first example of a Mannich reaction leading to a 12-membered pyridine-containing macrocycle.

引用

页码：1201 / 1204

页数：4

共 19 条

[1] [GdPCP2A(H2O)2]-:: A paramagnetic contrast agent designed for improved applications in magnetic resonance imaging [J].

Aime, S ;

Botta, M ;

Frullano, L ;

Crich, SG ;

Giovenzana, G ;

Pagliarin, R ;

Palmisano, G ;

Sirtori, FR ;

Sisti, M .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (21) :4017-4024

[2]

Aime S, 1998, MAGN RESON CHEM, V36, pS200, DOI 10.1002/(SICI)1097-458X(199806)36:13<S200::AID-OMR324>3.0.CO

[3]

2-H

[4] Lanthanide(III) chelates for NMR biomedical applications [J].

Aime, S ;

Botta, M ;

Fasano, M ;

Terreno, E .

CHEMICAL SOCIETY REVIEWS, 1998, 27 (01) :19-29

[5]

Aime S, 1999, CHEM-EUR J, V5, P1253, DOI 10.1002/(SICI)1521-3765(19990401)5:4<1253::AID-CHEM1253>3.3.CO

[6]

2-9

[7] MRI CONTRAST AGENTS - MACROCYCLIC LANTHANIDE(III) COMPLEXES WITH IMPROVED RELAXATION EFFICIENCY [J].

AIME, S ;

BOTTA, N ;

CRICH, SG ;

GIOVENZANA, GB ;

JOMMI, G ;

PAGLIARIN, R ;

SISTI, M .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (18) :1885-1886

[8]

AIME S, 1991, MAGN RESON CHEM, V29, P323

[9]

[Anonymous], 2001, ACOUSTIC CHARACTERIZ

[10] Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications [J].

Caravan, P ;

Ellison, JJ ;

McMurry, TJ ;

Lauffer, RB .

CHEMICAL REVIEWS, 1999, 99 (09) :2293-2352

← 1 2 →