Nobilisitine A and B, two masanane-type alkaloids from Clivia nobilis

被引：25

作者：

Evidente, A

Abou-Donia, AH

Darwish, FA

Amer, ME

Kassem, FF

Hammoda, HAM

Motta, A

机构：

[1] Univ Naples Federico II, Dipartimento Sci Chim Agrarie, I-80055 Portici, Italy

[2] Univ Alexandria, Dept Pharmacognosy, Alexandria, Egypt

[3] CNR, Ist Chim Mol Interesse Biol, I-80072 Arco, Italy

来源：

PHYTOCHEMISTRY | 1999年 / 51卷 / 08期

关键词：

Clivia nobilis; Amaryllidaceae; masanane-type alkaloids; nobilsiitine A and B; clivatine epimer;

D O I：

10.1016/S0031-9422(98)00714-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two masanane-type lactone alkaloids, named nobilisitine A and B, were isolated from Egyptian Clivia nobilis and characterized by spectroscopic and chemical methods. Both compounds showed contain the same [2]benzopyrano[3,4-g]indole ring system and therefore belong to the same subgroup of Amaryllidaceae alkaloids. In particular, nobilisitine A and B, reported as two new alkaloids, proved to be the 5 beta-hydroxy-3a,11c-epi-masan-7-one and the 3-hydroxybutanoyl ester of clivonine (5 alpha-hydroxy-5a-epi-masan-7-one), the alkaloid previously extracted from Clivia miniata and belonging to the same alkaloid subgroup. Nobilisitine B appears to be an epimer at the acyl side chain of clivatine. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1151 / 1155

页数：5

共 15 条

[1] CLIVONIDINE, A NEW ALKALOID FROM CLIVIA-MINIATA [J].