Epigenetic disorders and male subfertility

被引：97
作者：
Boissonnas, Celine Chalas [1 ]
Jouannet, Pierre [2 ]
Jammes, Helene [3 ]
机构：
[1] Univ Paris 05, Hop Cochin, AP HP, CECOS, F-75014 Paris, France
[2] Univ Paris 05, CERSES, UMR 8137, CNRS, F-75014 Paris, France
[3] INRA, Biol Dev & Reprod UMR1198, F-78352 Jouy En Josas, France
来源：
FERTILITY AND STERILITY | 2013年 / 99卷 / 03期
关键词：
Epigenetics; male infertility; methylation; histone; spermatozoal RNAs; MALE GERM-CELLS; PATERNAL METHYLATION IMPRINT; INHIBITOR TRICHOSTATIN-A; SPERM DNA METHYLATION; INFERTILE HUMAN MALES; MAMMALIAN DEVELOPMENT; MURINE SPERMATOGENESIS; SEVERE OLIGOZOOSPERMIA; PROTAMINE EXPRESSION; ABNORMAL METHYLATION;
D O I：
10.1016/j.fertnstert.2013.01.124
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To provide a link between epigenetics and male subfertility at the DNA, histone-protamine, and RNA levels and its consequences on fertilization and embryo development. Design: Review of the relevant literature. Setting: University-based clinical and research laboratories. Patient(s): Fertile and infertile men. Intervention(s): None. Main Outcome Measure(s): Critical review of the literature. Result(s): Epigenetic markers can be modified in infertile patients. Epigenetic modifications include methylation loss or gain on the global level and on imprinted genes, high levels of histone retention in spermatozoa, and deficiencies in some transcripts involved in spermatogenesis. Interestingly, these abnormalities are all linked together, because DNA methylation maintenance depends on DNA histone-protamine configuration which itself is stabilized by spermatozoal RNAs. Conclusion(s): The paternal genome has long been considered to be silent and passive in embryo formation. The epigenetic processes associated with the paternal DNA genome highlights its importance in male fertility as well as for embryo development. (Fertil Steril (R) 2013;99:624-31. (C) 2013 by American Society for Reproductive Medicine.)
引用
收藏
页码：624 / 631
页数：8
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